早产儿经导管动脉导管未闭后左心室收缩功能的变化。

IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Pediatric Cardiology Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI:10.4103/apc.apc_52_23
Aravinth Karunanandaa, Joseph Paolillo, Amanda Cook, Kamala Swayampakala, Matthew C Schwartz
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引用次数: 0

摘要

背景:经导管动脉导管未闭(PDA)术后早产新生儿左心室(LV)收缩功能的变化尚未得到很好的描述:我们对 2015 年 1 月 1 日至 2021 年 1 月 31 日期间在本中心接受经导管动脉导管关闭术的所有体重小于 3 千克的早产新生儿进行了回顾性鉴定。我们提取了闭合前后的左心室指数并进行了分析。在闭合后 24 小时,中位左心室射血分数(LVEF)(66% 四分位间距 [IQR] 12% vs. 61% IQR 12,P< 0.001)和中位左心室舒张末期维度 z 评分(3.3 IQR 1.8 vs. 1.4 IQR 2.6,P< 0.001)均下降,5 名(22%)新生儿的 LVEF P = 0.01)、术前左心室舒张末期容积较高(19 mL IQR 4 mL vs. 11 mL IQR 11,P = 0.03)、出生体重较高(940 g IQR 100 g vs. 760 g IQR 140,P = 0.04),并且与关闭术后 24 小时 LVEF ≥55% 的新生儿相比,更有可能在术中静脉注射钙剂(60% vs. 11%,P = 0.04)。结论在成功进行经导管 PDA 关闭术的早产新生儿中,23% 的新生儿在关闭术后出现 LVEF 异常。
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Changes in left ventricular systolic function after transcatheter patent ductus arteriosus closure in premature infants.

Background: Changes in left ventricular (LV) systolic function have not been well described in premature neonates after transcatheter patent ductus arteriosus (PDA) closure.

Methods and results: We retrospectively identified all premature neonates < 3 kg who underwent a transcatheter PDA closure at our center between January 1 2015 and January 31, 2021. LV indices before and after closure were extracted and an analysis was performed. Overall, 23 neonates were included with a mean procedural weight of 1894 ± 622 g. At 24 h after closure, the median left ventricular ejection fraction (LVEF) (66% interquartile range [IQR] 12% vs. 61% IQR 12, P< 0.001) and median LV end-diastolic dimension z-score (3.3 IQR 1.8 vs. 1.4 IQR 2.6, P < 0.001) both decreased and 5 (22%) neonates had an LVEF <55%. Patients who had an LVEF <55% at 24 h had a higher preprocedure LV end-diastolic dimension z-score (4.2 IQR 1.2 vs. 2.8 IQR 1.6, P = 0.01), a higher preprocedure LV end-diastolic volume (19 mL IQR 4 mL vs. 11 mL IQR 11, P = 0.03), a higher birth weight (940 g IQR 100 g vs. 760 g IQR 140, P = 0.04), and were more likely to receive intravenous calcium during the procedure (60% vs. 11%, P = 0.04) compared to those with an LVEF ≥55% at 24 h after closure. Of those with LVEF <55% at 24 h, all normalized before discharge.

Conclusion: In preterm neonates who underwent successful transcatheter PDA closure, 23% developed abnormal LVEF after closure and those with significant LV dilation before the procedure were at increased risk for the development of LVEF <55% after closure.

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来源期刊
Annals of Pediatric Cardiology
Annals of Pediatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
1.40
自引率
14.30%
发文量
51
审稿时长
23 weeks
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