构建相应的经验模型,以桥接热特性和热致性多羟胺的合成。

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2024-02-07 eCollection Date: 2024-01-01 DOI:10.1080/15685551.2024.2313268
Zichun Yan, D Andrew Brown, Trey Alpi, Jiro Nagatomi, O Thompson Mefford
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引用次数: 0

摘要

聚氧乙烯-聚氧丙烯嵌段共聚物)水凝胶的热致伸缩性能与多个变量有关。本研究特别关注聚合物的分子量、PEO 和 PPO 嵌段之间的摩尔比以及水溶液的浓度。精确控制聚合物的热致伸缩行为对此类材料的应用至关重要;因此,通过阴离子开环聚合(AROP)合成法研究了四支 PEO-PPO 嵌段共聚物的结构-性能关系。通过差示扫描量热仪(DSC)测量热致伸缩行为来研究结构-性能关系,并建立了一个经验模型,该模型在统计学上与收集到的数据相匹配。这一经验模型随后被用于设计临界胶束化温度 (CMT) 介于室温和生理温度之间的多羟胺。该模型通过三种聚合物进行了验证,它们的临界胶化温度为 308 K(35°C)。该经验模型在指导多羟胺的合成方面取得了巨大成功,其预测的 CMT 与观察到的 CMT 之间的温差小于 3 K。这项研究表明,使用经验模型来设定合成参数以控制聚合物产品的特性具有很大的潜力。
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Construction of a corresponding empirical model to bridge thermal properties and synthesis of thermoresponsive poloxamines.

The thermoresponsive properties of poloxamine (tetra-branch PEO-PPO block copolymer) hydrogels are related to several variables. Of particular interest to this study were the molecular weight of the polymer, the molar ratio between PEO and PPO blocks, and the concentration of the aqueous solution. Accurately controlling the thermoresponsive behaviors of the polymer is critical to the application of such materials; therefore, the structure-property relationship of tetra-branch PEO-PPO block copolymer was studied by synthesis via anionic ring-opening polymerization (AROP). The structure-property relationships were studied by measuring the thermoresponsive behavior via differential scanning calorimetry (DSC) and developing an empirical model which statistically fit the collected data. This empirical model was then used for designing poloxamines that have critical micellization temperatures (CMT) between room temperature and physiological temperature. The model was validated with three polymers that targeted a CMT of 308 K (35°C). The empirical model showed great success in guiding the synthesis of poloxamines showing a temperature difference of less than 3 K between the predicted and the observed CMTs. This study showed a great potential of using an empirical model to set synthesis parameters to control the properties of the polymer products.

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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
期刊最新文献
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