在母体饮食中补充巴西坚果(Bertholletia excelsa H.B.K.)可防止肥胖母亲的后代出现认知障碍。

IF 1.8 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Developmental Origins of Health and Disease Pub Date : 2023-12-01 Epub Date: 2024-02-12 DOI:10.1017/S2040174424000023
Lilian Fioravanso Apolinário, Amanda Tais Silva, Andrielli Pompermayer Rosa, Cleber da Silva Oliveira, Cleberson Lira, João Pedro Costa Dos Santos Guerra, Júlia Furtado Friedrich, Letícia Queiroz Rosa, Rodrigo Chelegão, Sílvia de Carvalho Campos Botelho, Valéria Dornelles Gindri Sinhorin, Júlio Cezar de Oliveira, Nádia Aléssio Velloso
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引用次数: 0

摘要

母体肥胖可能会引发后代长期的神经发育障碍。考虑到巴西坚果(Bertholletia excelsa H.B.K.)富含硒等营养物质,本研究旨在评估其对肥胖大鼠后代行为的影响及其与氧化应激的关系。从 60 天大到断奶,雌性 Wistar 大鼠被喂食高脂肪饮食(mHF)或添加 5%巴西坚果的高脂肪饮食(mHF/BN),而对照组母鼠(mCTL)则被喂食标准饮食或添加 5%巴西坚果的标准饮食(mBN)。雄性幼鼠在整个生命周期中都食用标准饲料,并在30天和90天大时接受行为任务,以评估焦虑和认知能力。90天大时进行生化评估。没有观察到后代的焦虑行为有任何改变。然而,mHF 组(oHF)的后代在 30 天和 90 天时表现出短期记忆受损,在 30 天时表现出长期记忆受损。巴西坚果可防止幼鼠(30 天)的短期记忆受损。虽然 oHF 组的血清硒浓度降低了,但所有组的血清过氧化氢酶浓度都降低了,脂质过氧化或蛋白质羰基化没有发生变化。补充巴西坚果母粮可防止后代出现短期和长期认知障碍,这可能与硒水平有关。
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Supplementation of the maternal diet with Brazil nut (Bertholletia excelsa H.B.K.) prevents cognitive impairment in the offspring of obese mothers.

Maternal obesity may trigger long-term neurodevelopmental disorders in offspring. Considering the benefits of the Brazil nut (Bertholletia excelsa H.B.K.), a rich source of nutrients such as selenium, this study aimed to evaluate its effect on the behavior of obese rat offspring and its relationship with oxidative stress. From 60 days of age until weaning, female Wistar rats were fed a high-fat diet (mHF) or an HF diet supplemented with 5% Brazil nut (mHF/BN), while control mothers (mCTL) were fed a standard diet or a standard diet supplemented with 5% Brazil nut (mBN). Male pups received a standard diet throughout life and, at 30 and 90 days old, were subjected to behavioral tasks to evaluate anxiety and cognition. Biochemical evaluations were performed at 90 days of age. No alterations were observed in the anxiety behavior of the offspring. However, the offspring of the mHF group (oHF) exhibited impaired short-term memory at 30 and 90 days of age and impaired long-term memory at 30 days. Short-term memory impairment was prevented by Brazil nuts in young rats (30 days). While the serum selenium concentration was reduced in the oHF group, the serum catalase concentration was reduced in all groups, without changes in lipid peroxidation or protein carbonylation. Brazil nut maternal diet supplementation prevented short- and long-term cognitive impairment in the offspring, which may be related to the selenium levels.

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来源期刊
Journal of Developmental Origins of Health and Disease
Journal of Developmental Origins of Health and Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.80
自引率
0.00%
发文量
145
审稿时长
6-12 weeks
期刊介绍: JDOHaD publishes leading research in the field of Developmental Origins of Health and Disease (DOHaD). The Journal focuses on the environment during early pre-natal and post-natal animal and human development, interactions between environmental and genetic factors, including environmental toxicants, and their influence on health and disease risk throughout the lifespan. JDOHaD publishes work on developmental programming, fetal and neonatal biology and physiology, early life nutrition, especially during the first 1,000 days of life, human ecology and evolution and Gene-Environment Interactions. JDOHaD also accepts manuscripts that address the social determinants or education of health and disease risk as they relate to the early life period, as well as the economic and health care costs of a poor start to life. Accordingly, JDOHaD is multi-disciplinary, with contributions from basic scientists working in the fields of physiology, biochemistry and nutrition, endocrinology and metabolism, developmental biology, molecular biology/ epigenetics, human biology/ anthropology, and evolutionary developmental biology. Moreover clinicians, nutritionists, epidemiologists, social scientists, economists, public health specialists and policy makers are very welcome to submit manuscripts. The journal includes original research articles, short communications and reviews, and has regular themed issues, with guest editors; it is also a platform for conference/workshop reports, and for opinion, comment and interaction.
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