Ruxandra Rosca, Dan Nicolae Paduraru, Alexandra Bolocan, Florentina Musat, Daniel Ion, Octavian Andronic
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引用次数: 0
摘要
腹股沟疝修补术是全世界最常见的外科手术之一。在这种情况下,要预防、诊断和治疗这种常见疾病,了解和识别风险因素和保护因素是必不可少的一步。长期以来,人们普遍认为肥胖是腹股沟疝发生的一个危险因素。研究提供了一些意想不到的数据,表明肥胖实际上可能是一个保护因素。本综述旨在概述这一主题,同时考虑到胶原蛋白分布和新陈代谢等系统方面的因素。在腹股沟疝气患者中,I 型胶原蛋白和 III 型胶原蛋白的比例下降,III 型胶原蛋白是造成腹壁薄弱的原因。肥胖患者的细胞外基质中胶原蛋白含量更丰富,尤其是 I 型胶原蛋白,这将产生强度和硬度。肥胖似乎确实是一个保护性因素,但为了了解其根本机制并选择最佳的手术方法,还需要进一步的研究。
A Comprehensive Review of Inguinal Hernia Occurrence in Obese Individuals.
Inguinal hernia repair is one of the most commonly performed surgical activities worldwide. Given the circumstances, understanding and identifying the risk and the protective factors is an essential step in order to prevent, diagnose and treat such a common condition. For a long time, obesity was generally considered to be a risk factor in the occurrence of an inguinal hernia. Studies have provided some unexpected data, suggesting that it might actually be a protective factor. This review aims to provide an overview on this topic, taking into account systemic aspects such as collagen distribution and metabolism. In inguinal hernia patients, the ratio between type I collagen and type III collagen is decreased, with type III collagen being responsible for the weakness of the abdominal wall. In obese patients, the extracellular matrix becomes richer in collagen, especially type I collagen, which will generate strength and stiffness. Obesity seems to be a protective factor indeed, but in order to understand the underlying mechanism and to choose the optimal surgical approach, further research is needed.