评估干细胞疗法对牙周健康的影响:临床研究的元分析。

Yu-Han Shao, Yi Song, Qiao-Li Feng, Yan Deng, Tao Tang
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引用次数: 0

摘要

目的:虽然探索干细胞再生牙周组织的临床试验已取得积极成果,但有关这一主题的系统文献综述却十分有限。为了更全面地了解干细胞对牙周再生的干预,本荟萃分析旨在评估干细胞对人类牙周再生的有益影响:方法:使用 "PubMed"、"Cochrane Library"、"Web of Science"、"Embase"、"Wanfang "和 "CNKI "来提取与利用干细胞修复牙周组织缺损相关的临床研究。该搜索包括截至2023年10月5日发表的研究。纳入标准要求研究比较基于干细胞的疗法和不含干细胞的疗法对牙周组织再生的疗效。使用Review Manager软件(5.4版)进行荟萃分析:这项荟萃分析综合了15项选定研究的结果,这些研究调查了干细胞干预对牙周组织再生的影响。与 "对照 "组相比,"干细胞 "组在术后3至12个月内临床附着水平(CAL)大幅下降。不过,各组之间在CAL增加方面没有发现明显差异。与 "对照 "组相比,"干细胞 "组的探囊深度(PPD)明显下降,特别是在超过6个月的随访期间,牙科干细胞治疗有明显改善。相反,在 PPD 的减少方面没有观察到明显差异。与 "对照 "组相比,"干细胞 "组的牙龈退缩(GR)在术后3至12个月明显减少。各组之间在牙龈退缩方面无明显差异。两组在骨水泥釉交界处-骨距离减少、骨下缺损减少或骨矿物质密度增加方面没有发现明显差异。此外,在牙龈指数、牙菌斑指数或角化牙龈宽度方面也未观察到明显变化:总之,虽然干细胞疗法为牙周缺陷治疗提供了广阔的前景,但目前的研究还存在明显的局限性。要为干细胞干预牙周炎提供更可靠的证据,需要进行更大规模、多中心、双盲、方法可靠的临床试验。
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Assessing the Impact of Stem Cell-based Therapy on Periodontal Health: A Meta-analysis of Clinical Studies.

Objective: While clinical trials exploring stem cells for regenerating periodontal tissues have demonstrated positive results, there is a limited availability of systematic literature reviews on this subject. To gain a more comprehensive understanding of stem cell interventions in periodontal regeneration, this meta-analysis is undertaken to assess the beneficial effects of stem cells in human periodontal regeneration.

Methods: "PubMed," "Cochrane Library," "Web of Science," "Embase," "Wanfang," and "CNKI," were used to extract clinical studies related to the utilization of stem cells in repairing periodontal tissue defects. This search included studies published up until October 5, 2023. The inclusion criteria required the studies to compare the efficacy of stem cell-based therapy with stem cell-free therapy for regenerating periodontal tissues. Meta-analysis was conducted using Review Manager software (version 5.4).

Results: This meta-analysis synthesized findings from 15 selected studies investigating the impact of stem cell interventions on periodontal tissue regeneration. The "stem cell" group displayed a substantial reduction in clinical attachment level (CAL) compared to the "control" group within 3 to 12 months post-surgery. However, no significant differences in CAL gain were found between groups. Probing pocket depth (PPD) significantly decreased in the "stem cell" group compared to the "control" group, particularly for follow-up periods exceeding 6 months, and dental stem cell treatment exhibited notable improvements. Conversely, no significant differences were observed in PPD reduction. Gingival recession (GR) significantly decreased in the "stem cell" group compared to the "control" group at 3 to 12 months post-surgery. No significant differences were observed in GR reduction between groups. No significant differences were identified in cementoenamel junction-bone distance reduction, infrabony defect reduction, or bone mineral density increase between the two groups. Furthermore, no significant changes were observed in the gingival index, plaque index, or width of keratinized gingiva.

Conclusion: In conclusion, while stem cell-based therapy offers promising prospects for periodontal defect treatment, there are notable limitations in the current body of research. Larger, multicenter, double-blind RCTs with robust methodologies are needed to provide more reliable evidence for stem cell-based intervention in periodontitis.

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