Adil Asghar, Ravi Kant Narayan, Nagavalli Basavanna Pushpa, Apurba Patra, Kumar Satish Ravi, R Shane Tubbs
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The meta-analysis computed the prevalence of normal variants of the PDS (92% of 10,514 subjects). Type 3 variants and \"descending\" subtypes of the main pancreatic duct (MPD) predominated in the pooled samples. The mean lengths of the MPD and accessory pancreatic duct (APD) were 16.53 cm and 3.36 cm, respectively. The mean diameters of the MPD at the head and the APD were 3.43 mm and 1.69 mm, respectively. The APD was present in only 41% of samples, and the long type predominated. The pancreatic ductal anatomy is highly variable, and the incorrect identification of variants may be challenging for surgeons during ductal anastomosis with gut, failure to which may often cause ductal obstruction or pseudocysts formation.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"31-44"},"PeriodicalIF":1.4000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968189/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring the variations of the pancreatic ductal system: a systematic review and meta-analysis of observational studies.\",\"authors\":\"Adil Asghar, Ravi Kant Narayan, Nagavalli Basavanna Pushpa, Apurba Patra, Kumar Satish Ravi, R Shane Tubbs\",\"doi\":\"10.5115/acb.23.148\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The exocrine part of the pancreas has a duct system called the pancreatic ductal system (PDS). Its mechanism of development is complex, and any reorganization during early embryogenesis can give rise to anatomical variants. The aim of this study is to collect, classify, and analyze published evidence on the importance of anatomical variants of the PDS, addressing gaps in our understanding of such variations. The MEDLINE, Web of Science, Embase, and Google Scholar databases were searched to identify publications relevant to this review. R studio with meta-package was used for data extraction, risk of bias estimation, and statistical analysis. A total of 64 studies out of 1,778 proved suitable for this review and metanalysis. The meta-analysis computed the prevalence of normal variants of the PDS (92% of 10,514 subjects). Type 3 variants and \\\"descending\\\" subtypes of the main pancreatic duct (MPD) predominated in the pooled samples. The mean lengths of the MPD and accessory pancreatic duct (APD) were 16.53 cm and 3.36 cm, respectively. 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The pancreatic ductal anatomy is highly variable, and the incorrect identification of variants may be challenging for surgeons during ductal anastomosis with gut, failure to which may often cause ductal obstruction or pseudocysts formation.</p>\",\"PeriodicalId\":7831,\"journal\":{\"name\":\"Anatomy & Cell Biology\",\"volume\":\" \",\"pages\":\"31-44\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968189/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anatomy & Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5115/acb.23.148\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ANATOMY & MORPHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anatomy & Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5115/acb.23.148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
胰腺的外分泌部分有一个管道系统,称为胰腺导管系统(PDS)。其发育机制十分复杂,早期胚胎发育过程中的任何重组都可能导致解剖变异。本研究旨在收集、分类和分析已发表的有关胰腺导管系统解剖变异重要性的证据,弥补我们对此类变异认识的不足。研究人员检索了 MEDLINE、Web of Science、Embase 和 Google Scholar 数据库,以确定与本综述相关的出版物。使用带有元软件包的 R studio 进行数据提取、偏倚风险估计和统计分析。在 1,778 项研究中,共有 64 项研究被证明适合本综述和荟萃分析。荟萃分析计算了 PDS 正常变异的流行率(10,514 名受试者中的 92%)。在汇总样本中,主胰管(MPD)的 3 型变异和 "下降 "亚型占多数。主胰管和附属胰管(APD)的平均长度分别为 16.53 厘米和 3.36 厘米。MPD头部和APD的平均直径分别为3.43毫米和1.69毫米。只有 41% 的样本存在 APD,且以长型为主。胰腺导管解剖结构千变万化,在导管与肠道吻合时,错误地识别变异体可能会给外科医生带来挑战,失败的吻合往往会导致导管阻塞或假性囊肿的形成。
Exploring the variations of the pancreatic ductal system: a systematic review and meta-analysis of observational studies.
The exocrine part of the pancreas has a duct system called the pancreatic ductal system (PDS). Its mechanism of development is complex, and any reorganization during early embryogenesis can give rise to anatomical variants. The aim of this study is to collect, classify, and analyze published evidence on the importance of anatomical variants of the PDS, addressing gaps in our understanding of such variations. The MEDLINE, Web of Science, Embase, and Google Scholar databases were searched to identify publications relevant to this review. R studio with meta-package was used for data extraction, risk of bias estimation, and statistical analysis. A total of 64 studies out of 1,778 proved suitable for this review and metanalysis. The meta-analysis computed the prevalence of normal variants of the PDS (92% of 10,514 subjects). Type 3 variants and "descending" subtypes of the main pancreatic duct (MPD) predominated in the pooled samples. The mean lengths of the MPD and accessory pancreatic duct (APD) were 16.53 cm and 3.36 cm, respectively. The mean diameters of the MPD at the head and the APD were 3.43 mm and 1.69 mm, respectively. The APD was present in only 41% of samples, and the long type predominated. The pancreatic ductal anatomy is highly variable, and the incorrect identification of variants may be challenging for surgeons during ductal anastomosis with gut, failure to which may often cause ductal obstruction or pseudocysts formation.