George Angelakakis, Mallika Varkhedi, Toriana R Dabkowski, Michael J Diaz, Michelle Yeagley, George Blanck
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引用次数: 0
摘要
小儿急性淋巴细胞白血病（ALL）中某些基因的拷贝数变异（CNV）会影响基因表达水平。在此，我们旨在研究CNV在小儿B-ALL和T-ALL中的潜在预后作用。利用代表 TARGET-ALL-P2 数据集中病例的基因组学文件，分析了常见的参与 ALL 发育的基因的 CNVs。代表SOX11、PDGFRB和MDK拷贝数增加的病例ID表示B-ALL的总生存概率较低（logrank p=0.021、p=0.0052、p=0.019）。这些数据支持继续研究将CNVs作为小儿B-ALL的临床预后生物标志物。
B-cell ALL with SOX11 gene amplification associates with a worse outcome.
Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for SOX11, PDGFRB, and MDK represented a worse overall survival probability specifically for B-ALL (logrank p=0.021, p=0.0052, p=0.019, respectively). These data support the continued investigation of using CNVs for clinical prognostic biomarkers for pediatric B-ALL.
期刊介绍：
Cell Cycle is a bi-weekly peer-reviewed journal of high priority research from all areas of cell biology. Cell Cycle covers all topics from yeast to man, from DNA to function, from development to aging, from stem cells to cell senescence, from metabolism to cell death, from cancer to neurobiology, from molecular biology to therapeutics. Our goal is fast publication of outstanding research.
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