超级增强子:对胃癌的影响

IF 6.4 2区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2024-01-01 DOI:10.1016/j.mrrev.2024.108489
Yizhou Huang , Yanfei Huo , Linying Huang , Long Zhang , Yanxiu Zheng , Nasha Zhang , Ming Yang
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引用次数: 0

摘要

胃癌(GC)是全球发病率第五高的恶性肿瘤,也是导致癌症相关死亡的第三大原因。尽管人们不断努力提高各种疗法(化疗、外科干预、分子靶向疗法、免疫疗法)的疗效,但胃癌患者的预后仍然很差。这可能主要是由于人们对 GC 复杂病因的了解有限。重要的是,表观遗传修饰和改变在 GC 的发展过程中至关重要。超级增强子(SE)是一大簇相邻的增强子,能极大地激活转录。超级增强子通过增强特定癌基因的转录来维持细胞特异性。在这篇综述中,我们系统地总结了SE如何参与GC的发育,包括GC中的SE图谱、GC中的SE靶基因以及治疗GC的与SE功能相关的干预措施。
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Super-enhancers: Implications in gastric cancer

Gastric cancer (GC) is the fifth most prevalent malignancy and the third leading cause of cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of various therapeutics (chemotherapy, surgical interventions, molecular-targeted therapies, immunotherapies), the prognosis for patients with GC remains poor. This might be predominantly due to the limited understanding of the complicated etiology of GC. Importantly, epigenetic modifications and alterations are crucial during GC development. Super-enhancers (SEs) are a large cluster of adjacent enhancers that greatly activate transcription. SEs sustain cell-specific identity by enhancing the transcription of specific oncogenes. In this review, we systematically summarize how SEs are involved in GC development, including the SE landscape in GC, the SE target genes in GC, and the interventions related to SE functions for treating GC.

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来源期刊
CiteScore
12.20
自引率
1.90%
发文量
22
审稿时长
15.7 weeks
期刊介绍: The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
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