在胰岛素分泌细胞的维持、分化和内分泌活性中操纵音猬信号通路:系统综述

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI:10.30476/ijms.2023.95425.2678
Dian Dayer, Vahid Bayati, Mina Ebrahimi
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引用次数: 0

摘要

背景:一些研究评估了操纵声刺猬(Shh)信号通路以产生更有效的胰岛素分泌细胞(IPCs)的方法。在一项系统性综述中,我们评估了有关抑制或激活 Shh 通路对 IPCs 的产生、分化、维持和内分泌活性的影响的体外和体内研究:方法:利用 2000 年 1 月至 2022 年 11 月间发表的所有可用实验研究进行了系统回顾。该综述旨在确定 Shh 操作对干细胞(SCs)分化为 IPCs 的影响。研究人员使用医学主题词提取了关键词和短语,并在 Web of Science、Embase、ProQuest、PubMed、Scopus 和 Cochrane Library 数据库中进行了全面检索。纳入标准为操纵 SCs 中的 Shh、SCs 分化为 IPCs 以及成熟 IPCs 的内分泌活性。数据不完整和重复的文章被排除在外:结果:共初步筛选出 208 篇文章,其中 11 篇被纳入研究。研究证实,在终末内胚层阶段抑制 Shh 可产生功能性 IPCs。一些研究表明,Shh 在分化晚期重新激活对产生有效的 IPCs 非常重要。有研究认为,成熟胰腺β细胞中的Shh基线浓度会影响细胞的胰岛素分泌和内分泌活动。然而,Shh在胰腺β细胞中过度表达最终会导致内分泌功能失调和葡萄糖感应胰岛素分泌不足:结论:准确操纵 Shh 信号通路是生产和维持功能性 IPC 的有效方法。
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Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review.

Background: Some studies have evaluated the manipulation of the sonic hedgehog (Shh) signaling pathway to generate more efficient insulin-producing cells (IPCs). In a systematic review, we evaluated in vitro and in vivo studies on the effect of inhibition or activation of the Shh pathway on the production, differentiation, maintenance, and endocrine activity of IPCs.

Methods: A systematic review was conducted using all available experimental studies published between January 2000 and November 2022. The review aimed at determining the effect of Shh manipulation on the differentiation of stem cells (SCs) into IPCs. Keywords and phrases using medical subject headings were extracted, and a complete search was performed in Web of Science, Embase, ProQuest, PubMed, Scopus, and Cochrane Library databases. The inclusion criteria were manipulation of Shh in SCs, SCs differentiation into IPCs, and endocrine activity of mature IPCs. Articles with incomplete data and duplications were excluded.

Results: A total of 208 articles were initially identified, out of which 11 articles were included in the study. The effect of Shh inhibition in the definitive endoderm stage to produce functional IPCs were confirmed. Some studies showed the importance of Shh re-activation at late-stage differentiation for the generation of efficient IPCs. It is proposed that baseline concentrations of Shh in mature pancreatic β-cells affect insulin secretion and endocrine activities of the cells. However, Shh overexpression in pancreatic β-cells ultimately leads to improper endocrine function and inadequate glucose-sensing insulin secretion.

Conclusion: Accurate manipulation of the Shh signaling pathway can be an effective approach in the production and maintenance of functional IPCs.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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