自身免疫性疾病中淋巴细胞的代谢失调。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-02-13 DOI:10.1016/j.tem.2024.01.005

Shuyi Wang, Niansheng Yang, Hui Zhang

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引用次数: 0

摘要

淋巴细胞对于抵御感染和癌症的保护性免疫至关重要；然而，免疫失调可导致自身免疫性疾病，如系统性红斑狼疮（SLE）和类风湿性关节炎（RA）。代谢适应性控制着淋巴细胞的命运；因此，代谢重编程可能有助于自身免疫性疾病的发病机制。在此，我们总结了有关代谢重编程如何决定系统性红斑狼疮和类风湿性关节炎中淋巴细胞的自反应性和促炎性的最新研究进展，揭示其分子机制，并为人类自身免疫性疾病提供治疗靶点。

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Metabolic dysregulation of lymphocytes in autoimmune diseases.

Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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