间充质干细胞衍生外泌体对过敏性气道炎症的治疗潜力

IF 3.7 4区医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2024-02-15 DOI:10.1016/j.cellimm.2024.104813

Mahvash Sadeghi , Mojgan Mohammadi , Jalil Tavakol Afshari , Sara Iranparast , Bahareh Ansari , Sajad Dehnavi

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引用次数: 0

摘要

间充质干细胞（MSCs）具有免疫调节能力，已被广泛用作治疗各种炎症性疾病的细胞疗法。多项研究表明，间充质干细胞最有益的作用与间充质干细胞衍生的外泌体有关。外泌体是一种纳米级细胞外囊泡，含有重要的生物大分子，如 RNA、microRNA（miRNA）、DNA、生长因子、酶、趋化因子和细胞因子，可调节免疫细胞功能和实质细胞存活。最近，外泌体，尤其是间充质干细胞衍生的外泌体，被证明对过敏性气道炎症具有保护作用。本综述重点探讨了间充质干细胞衍生的外泌体作为纳米级递送系统在治疗过敏性气道炎症中的免疫调节潜力。

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Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation

Due to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs (miRNAs), DNA, growth factors, enzymes, chemokines, and cytokines that regulate immune cell functions and parenchymal cell survival. Recently, exosomes, especially MSC-derived exosomes, have been shown to have protective effects in allergic airway inflammation. This review focused on the immune-regulatory potential of MSC-derived exosomes as nanoscale delivery systems in the treatment of allergic airway inflammation.

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.