在ABCB11930_1931del TC基因同源的猫体内施用标签剂量的含依普霉素的杀寄生虫药会导致神经系统中毒。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-02-17 DOI:10.1111/jvp.13431
Katrina L. Mealey, Neal S. Burke, Nicolas F. Villarino, Michael H. Court, Jennifer P. Heusser
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引用次数: 0

摘要

猫科动物的 MDR1 基因突变(ABCB11930_1931delTC)与局部使用标明用于猫科动物的埃普瑞诺菌素产品后出现的神经系统中毒症有关。我们从提交样本进行 ABCB11930_1931delTC 基因分型的兽医那里收集了相关信息。在大多数情况下,提交的表格都表明发生了涉及埃普瑞诺菌素的不良事件,在其他情况下,会与提交样本的兽医取得联系,以确定患者是否发生了涉及埃普瑞诺菌素的药物不良事件。如果是,则会获取更多信息,以确定该病例是否符合纳入标准。14 个病例与伊普瑞诺菌素中毒高度一致。8 只猫是 ABCB11930_1931del TC 的同源基因(3 只死亡;5 只康复)。6 只猫为同型野生型(2 只死亡;4 只康复)。观察到的 ABCB11930_1931delTC 频率(57%)高于猫科动物群体中的预期频率(≤1%)(Fisher Exact 检验,p
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Application of eprinomectin-containing parasiticides at label doses causes neurological toxicosis in cats homozygous for ABCB11930_1931del TC

The feline MDR1 mutation (ABCB11930_1931delTC) has been associated with neurological toxicosis after topical application of eprinomectin products labeled for feline use. Information was collected from veterinarians who submitted samples for ABCB11930_1931delTC genotyping. In most cases, the submission form indicated an adverse event involving eprinomectin, in other cases submitting veterinarians were contacted to determine whether the patient had experienced an adverse drug event involving eprinomectin. If so, additional information was obtained to determine whether the case met inclusion criteria. 14 cases were highly consistent with eprinomectin toxicosis. Eight cats were homozygous for ABCB11930_1931del TC (3 died; 5 recovered). Six cats were homozygous wildtype (2 died; 4 recovered). The observed ABCB11930_1931delTC frequency (57%) was higher than the expected frequency (≤1%) in the feline population (Fisher Exact test, p < 0.01). Among wildtype cats, four were concurrently treated with potential competitive inhibitors of P-glycoprotein. Results indicate that topical eprinomectin products, should be avoided in cats homozygous for ABCB11930_1931delTC. This is a serious, preventable adverse event occurring in an identifiable subpopulation treated with FDA-approved products in accordance with label directions. Acquired P-glycoprotein deficiency resulting from drug interactions may enhance susceptibility to eprinomectin-induced neurological toxicosis in any cat, regardless of ABCB1 genotype.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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