使用游离烯丙基醇催化羰基衍生物的不对称烯丙基α-烷基化的最新进展

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY ACS Organic & Inorganic Au Pub Date : 2024-02-10 DOI:10.1021/acsorginorgau.3c00065
Diego A. Alonso, Beatriz Maciá, Isidro M. Pastor and Alejandro Baeza*, 
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摘要

在过去几年中,开发更可持续、更简单的方法以尽量减少废弃有机物的产生在有机合成化学中占据了重要地位。因此,许多人致力于改进已经众所周知的成功方法,如羰基化合物的不对称烯丙基烯丙基化反应,也就不足为奇了。在这一转化过程中使用游离醇作为烷基化剂,是在这一意义上向前迈出的一步,因为它最大限度地减少了废物的产生和底物的操作。在这篇综述中,我们旨在收集描述这种策略的最新方法,特别关注反应机理及其合成应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Recent Advances on the Catalytic Asymmetric Allylic α-Alkylation of Carbonyl Derivatives Using Free Allylic Alcohols

During the last years, the development of more sustainable and straightforward methodologies to minimize the generation of waste organic substances has acquired high importance within synthetic organic chemistry. Therefore, it is not surprising that many efforts are devoted to ameliorating already well-known successful methodologies, that is, the case of the asymmetric allylic allylation reaction of carbonyl compounds. The use of free alcohols as alkylating agents in this transformation represents a step forward in this sense since it minimizes waste production and the substrate manipulation. In this review, we aim to gather the most recent methodologies describing this strategy by paying special attention to the reaction mechanisms, as well as their synthetic applications.

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来源期刊
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au 有机化学、无机化学-
CiteScore
4.10
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0.00%
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0
期刊介绍: ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.
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