R. Martínez-Martínez, J. L. Áyala-Herrera, Alejandro Nava Carmona, Rubén Abraham Domínguez Pérez, Berenice Hernández Castro, L. F. Espinosa-Cristóbal, Carlos Abud Mendoza
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引用次数: 0
摘要
Th17/Treg细胞和牙龈脓疱病与类风湿性关节炎（RA）和牙周炎（PE）有关。该研究旨在确定并比较健康受试者（HS）和 PE、RA 和 PE/RA 患者的 Th17/Treg 细胞以及牙龈脓疱疮对该细胞群的影响。通过实时 PCR 检测牙龈脓毒性杆菌的拷贝数，并使用流式细胞术分析 Th17/Treg 细胞。在这项研究中，RA 患者的 PE 增加了牙龈脓疱病菌 DNA 的拷贝数，提高了 Th17 细胞的百分比，同时也增加了 Treg 细胞的数量和调节能力。牙周炎会影响类风湿性关节炎患者的免疫系统，增加促炎症细胞的比例，这可能会影响该人群的炎症状况。
Influence of Periodontitis on Th17/Treg Percentages in Patients with Rheumatoid Arthritis
Th17/Treg cells and P. gingivalis have been implicated in rheumatoid arthritis (RA) and periodontitis (PE). The aim was to determine and compare Th17/Treg cells and the influence of P. gingivalis on this cell population in healthy subjects (HS) and patients with PE, RA, and PE/RA. The number of copies of P. gingivalis was performed by real-time PCR and flow cytometry was used to analyze Th17/Treg cells. In this study, PE in patients with RA increased the number of DNA copies of P. gingivalis, increasing the percentages of Th17 cells, as well as the number and regulation of Treg cells. Periodontitis influences the immune system, increasing the percentage of pro-inflammatory cells in patients with rheumatoid arthritis, which may could influence the inflammatory condition of this population.
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