基因组工程作为一种癌症治疗方法：全面回顾

Advanced Genetics Pub Date : 2024-02-05 DOI:10.1002/ggn2.202300201

Jack Gemayel, Alain Chebly, H. Kourie, Colette Hanna, Kayane Mheidly, Melissa Mhanna, Farah Karam, Daniel Ghoussaini, Paula El Najjar, Charbel Khalil

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引用次数: 0

摘要

癌症是导致死亡的首要原因之一。人类基因组随着时间的推移保持稳定。然而，人类活动和环境因素有能力影响某些类型突变的发生率。这与异种生物的过度繁殖和工业发展有关，它们正在扩大癌症的发病范围。针对癌症的免疫反应机制已被广泛研究。基因组编辑改变了基于基因组的人体免疫治疗过程，开创了癌症治疗的新纪元。在这篇综述中，近期的癌症免疫疗法和基因组工程技术的应用主要集中在以下几个方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review

Cancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop. The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome‐based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.

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