控制不佳的糖尿病老年患者空腹 C 肽水平与腹部脂肪组织厚度和胰腺大小的相关性

IF 1 Q4 ENDOCRINOLOGY & METABOLISM Diabetes epidemiology and management Pub Date : 2024-02-09 DOI:10.1016/j.deman.2024.100207
Pratibha Pereira , Jehath Syed , Sri Harsha Chalasani , Tejeswini C J , Shilpa Avarebeel , Kshama Ramesh
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引用次数: 0

摘要

背景胰岛素抵抗(IR)和糖尿病是老年患者中常见的慢性疾病,可能导致腹部脂肪组织沉积和胰腺体积增大。方法在一家三甲医院的老年门诊部进行了一项为期六个月的横断面研究,目的是对控制不佳的老年糖尿病患者的空腹 C 肽水平、腹部脂肪组织厚度和胰腺体积进行相关分析。HBA1c水平为7%的老年糖尿病患者在征得本人同意后入选。采用标准实验室技术测量了体重指数(BMI)、空腹 C 肽、腹部脂肪组织厚度和胰腺大小。所得数据按类别进行评估,并以[n (%)]表示。两组患者的比较采用 T 检验(P < 0.05)。研究结果显示,皮下脂肪和腹膜前脂肪厚度与空腹 c 肽水平无明显相关性(p = 0.801,p = 0.316)。不过,空腹 c 肽水平与胰腺大小有明显相关性(p = 0.001)。结论腹膜外脂肪厚度和胰腺大小可与 C 肽一起作为 IR 的替代标记物。所有未得到控制的 2 型糖尿病患者都需要进一步评估,并探索其致病过程。肥胖症评估必须成为未控制型糖尿病管理的一部分。
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Correlation of fasting C-peptide levels with abdominal adipose tissue thickness and pancreatic size amongst poorly controlled diabetic elderly patients

Background

Insulin resistance (IR) and diabetes are common chronic conditions amongst elderly patients, that may lead to increase in abdominal adipose tissue deposits and pancreatic size.

Methods

A cross-sectional study was conducted in the geriatric OPD in a tertiary care hospital for a period of six months to correlate fasting C-peptide levels, abdominal adipose tissue thickness, and pancreatic size in poorly controlled diabetic elderly patients. Diabetic elderly patients with HBA1c level >7 % were enrolled with their consent. Body mass index (BMI), fasting C-peptide, abdominal adipose tissue thickness and pancreatic size were measured using standard laboratory techniques. The data obtained were assessed categorically and represented as [n (%)]. T-test was used to compare the two groups (p < 0.05).

Results

A total of 101 patients were enrolled. The study results showed no significant correlation between subcutaneous fat and pre-peritoneal fat thickness; and fasting c-peptide levels (p = 0.801, p = 0.316). However, there was a significant correlation between the fasting c-peptide levels and pancreatic size (p = 0.001). It was also observed the study participants had a decreased pancreatic size, with the mean size being 4.837 cm in males, and 4.4418 cm in females.

Conclusion

Intra-peritoneal fat thickness and pancreatic size can be used as surrogate marker for IR along with C-peptide. All elderly with uncontrolled type 2 diabetes mellitus behaving like type 1 diabetes mellitus needs further evaluation and pathogenic process must be explored. Sarcopenic obesity evaluation must be a part of uncontrolled type diabetes mellitus management.

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来源期刊
Diabetes epidemiology and management
Diabetes epidemiology and management Endocrinology, Diabetes and Metabolism, Public Health and Health Policy
CiteScore
1.10
自引率
0.00%
发文量
0
审稿时长
14 days
期刊最新文献
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