巨细胞心肌炎的联合免疫抑制治疗:病例报告

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Italian Journal of Medicine Pub Date : 2024-02-09 DOI:10.4081/itjm.2024.1700
F. Iebba, Vera Elena Bottari, Fiorella Di Sora, M. Mallus, R. M. Manfredi, Francesco Prati
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引用次数: 0

摘要

巨细胞心肌炎(GCM)是一种罕见的、通常是暴发性的自身免疫性疾病。动物模型、与其他免疫性疾病的关联以及免疫抑制剂的疗效也支持 GCM 的免疫介导发病机制。GCM 的诊断基于心内膜活检。GCM 是一种孤儿病。心脏移植是有效的,但高达 25% 的移植患者会复发。免疫抑制剂已被证明是治疗 GCM 的潜在药物。在本病例报告中,使用环孢素、硫唑嘌呤和泼尼松后,患者病情得到了迅速而持久的缓解,证明了联合免疫抑制疗法在改善这种心脏病长期预后方面的作用。
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Combined immunosuppressive treatment for giant cell myocarditis: a case report
Giant cell myocarditis (GCM) is a rare and often fulminant autoimmune disease. The immune-mediated pathogenesis of GCM is also supported by animal models, association with other immunological diseases and therapeutic efficacy of immunosuppressive drugs. The diagnosis of GCM is based on endomyocardial biopsy. GCM is an orphan disease. Heart transplantation is effective but up to 25% of transplanted patients experience disease recurrence. Immunosuppressive drugs have been shown to be potential therapeutic agents for GCM. In the present case report, the prescription of cyclosporine, azathioprine and prednisone resulted in a rapid and prolonged remission in support of the role of a combined immunosuppressive regimen in improving the long-term prognosis of this cardiac pathology.
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来源期刊
Italian Journal of Medicine
Italian Journal of Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
3
审稿时长
10 weeks
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