R Laaksonen, A Niiranen, M Iivanainen, K Mattson, L Holsti, M Färkkilä, K Cantell
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Dementia-like, largely reversible syndrome after cranial irradiation and prolonged interferon treatment.
An elderly man with small cell lung cancer developed a largely reversible, dementia-like syndrome after cranial irradiation and prolonged treatment with interferon (IFN). The development of the symptoms started 2 months after cranial irradiation following more than 2 years of IFN treatment. The behavioral impairment did not suggest any specific brain localization. The dementia-like behaviour may be due to a combined effect of irradiation and IFN.
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