色素接触性皮炎:最新综述

Y. Bhat, Mohd Shurjeel Ul Islam, Sheikh Javeed Sultan
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引用次数: 0

摘要

色素接触性皮炎(PCD)是一种因反复接触低强度过敏原而引起的疾病,通常表现为影响菲茨帕特里克皮肤 IV-VI 型的斑点状或网状板灰色素沉着。发病机制尚不清楚,但过敏致敏、遗传、紫外线照射和自身免疫导致的 IV 型超敏反应可能是原因之一。临床检查、皮肤镜检查、斑贴/照相斑贴试验、组织病理学以及最近推出的新型反射共聚焦显微镜和多模态皮肤成像系统都有助于诊断。有几种接触性过敏原与 PCD 有关,但从印度的角度来看,Kumkum 和对苯二胺是罪魁祸首。只要诊断出 PCD,贴片测试就会发挥重要作用,这主要是由于接触性过敏原所致。与 PCD 相关的畸形会对社会接受度、心理健康和自尊造成毁灭性的心理影响。避免接触过敏原、涂抹广谱防晒霜和采取防晒措施是治疗该病的一般措施。
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Pigmented contact dermatitis: An updated review
Pigmented contact dermatitis (PCD) is a disorder brought on by repeated exposure to low-intensity allergens, usually presenting as blotchy or reticulate slate-gray pigmentation affecting Fitzpatrick skin type IV-VI. The pathogenesis remains unclear; however, type IV hypersensitivity reactions due to allergic sensitization, genetics, ultraviolet exposure, and autoimmunity are to blame. Clinical examination, dermoscopy, patch/photo patch testing, histopathology, and recently, a novel reflectance confocal microscopy and multimodality skin imaging system aid in the diagnosis. Several contact allergens have been linked to PCD, but from an Indian perspective, Kumkum and Paraphenylenediamine are the incriminating agents. Patch testing plays an immense role whenever PCD is diagnosed, primarily due to contact allergens. Devastating psychological impacts can result from PCD-related deformity on social acceptance, mental health, and self-esteem. Avoiding allergens, wearing broad-spectrum sunscreen, and engaging in sun-protective behavior are general measures for treating the condition.
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