利用电纺丝技术制造含有缓释药剂的生物可降解纳米医疗贴片

Afroj Ayyaj Shaikh, S. J. Anbhule
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引用次数: 0

摘要

通过电纺合成聚合物 PVA 和 PVP(每种聚合物 10%W),并添加各种药物(如双氯芬酸脱乙胺和庆大霉素,浓度各为 5%W),制成了负载长效药物(每种药物单独)的纳米聚合物(自显影)医用贴片。使用扫描电子显微镜(SEM)和 X 射线衍射(XRD)进一步研究了制得样品的形态结构,然后将其制成医用粘合剂,并直接在人手上进行测试。事实证明,这种方法可以有效地将药物输送到患处,而无需使用任何中间媒介。这种方法使用相对简单,可安全用于医疗用途,而且成本低廉,因为生产过程中不需要昂贵的工业设备。
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Fabrication of biodegradable nano medical patches incorporating a sustained-release pharmacological agent using electro-spinning technique
Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug (each substance separately) were created by electro-spinning synthetic polymers PVA and PVP at a rate of 10%W for each polymer and adding various medicinal substances, such as diclofenac de ethylamine and gentamicin, in concentrations of 5%w each. The morphological structure of the produced samples was further studied using a scanning electron microscope (SEM) and X-ray diffraction (XRD) before they were turned into a medical adhesive and tested directly on a human hand. This approach has already proven to be effective in delivering the medicine to the affected area without the use of any intermediaries. It is relatively simple to use, safe for medical usage, and inexpensive due to the lack of expensive industrial apparatus required for production.
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