一名多发性硬化症患者在接受特立氟胺治疗后发生急性缺血性中风:一个棘手的病例

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Therapeutic Research-clinical and Experimental Pub Date : 2024-01-01 DOI:10.1016/j.curtheres.2024.100732
Arsh Haj Mohamad Ebrahim Ketabforoush MD , Armin Tajik MD , Mohammad Amin Habibi MD , Nahid Abbasi Khoshsirat MD
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引用次数: 0

摘要

多发性硬化症是中枢神经系统的一种自身免疫性疾病,在这种疾病中,包括动脉粥样硬化在内的血管事件更为常见,进展也更快。特立氟胺(TFN)是一种口服药物,研究表明其副作用小、疗效好。本文介绍了一位患有多发性硬化症的中年女性,她的用药改为特立氟胺。35 天后,她出现了局灶性神经症状,检查报告显示为腔隙性梗死。在排除了急性缺血性中风的潜在病因(如血管和风湿病因素)后,唯一可确定的因素是引入了一种新药。将 TFN 确定为致病因素的过程需要在今后的研究中进一步澄清。
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Acute Ischemic Stroke in a Patient with Multiple Sclerosis after Initiating Teriflunomide Treatment: A Challenging Case

Multiple sclerosis is an autoimmune disease of the central nervous system, during which vascular events, including atherosclerosis, are more common and progress faster. Teriflunomide (TFN) is an oral drug that studies have indicated has low side effects alongside high efficiency. In this article, a middle-aged woman with multiple sclerosis was introduced, whose medication was changed to TFN. Thirty-five days later, she presented with focal neurologic symptoms, and investigations reported a lacunar infarction. Having excluded potential causes of acute ischemic stroke, such as vascular and rheumatologic factors, the only identifiable factor was the introduction of a new medication. The process of conclusively attributing TFN as the causative agent requires further clarification in future studies.

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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
31
审稿时长
3 months
期刊介绍: We also encourage the submission of manuscripts presenting preclinical and very preliminary research that may stimulate further investigation of potentially relevant findings, as well as in-depth review articles on specific therapies or disease states, and applied health delivery or pharmacoeconomics. CTR encourages and supports the submission of manuscripts describing: • Interventions designed to understand or improve human health, disease treatment or disease prevention; • Studies that focus on problems that are uncommon in resource-rich countries; • Research that is "under-published" because of limited access to monetary resources such as English language support and Open Access fees (CTR offers deeply discounted English language editing); • Republication of articles previously published in non-English journals (eg, evidence-based guidelines) which could be useful if translated into English; • Preclinical and clinical product development studies that are not pursued for further investigation based upon early phase results.
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