锝-99m 和铼与 N,N'-三价配体和 2-(癸硫基)-6-异氰基己酸甲酯的 "2+1B "三羰基配合物

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR Radiochemistry Pub Date : 2024-02-19 DOI:10.1134/S1066362223060085

A. E. Miroslavov, V. V. Kuz’min, A. P. Sakhonenkova, M. Yu. Tyupina, G. V. Sidorenko, A. R. Kochergina, V. A. Polukeev

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摘要

摘要通式为[M(CO)3(N^N)CN(CH2)4CH(COOMe)SC10H21]-ClO4 的 "2+1B "三羰基配合物，其中 M = 99mTc 或 Re，N^N = 2、M(CO)3(N^N)(MeOH)]ClO4 与 2-(癸硫基)-6-异氰基己酸甲酯在甲醇中的反应制备了[M(CO)3(N^N)(MeOH)]-ClO4。通过 1H NMR 和红外光谱分离并鉴定了铼配合物。高效液相色谱法证实了锝-99m 复合物的形成。测量了锝络合物的亲脂性。

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“2+1B” Tricarbonyl Complexes of Technetium-99m and Rhenium with N,N '-Bidentate Ligands and Methyl 2-(Decylthio)-6-isocyanohexanoate

“2+1_B” tricarbonyl complexes of the general formula [M(CO)₃(N^N)CN(CH₂)₄CH(COOMe)SC₁₀H₂₁]-ClO₄, where M = ^99mTc or Re, N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [M(CO)₃(N^N)(MeOH)]ClO₄ with methyl 2-(decylthio)-6-isocyanohexanoate in methanol. The rhenium complexes were isolated and characterized by ¹H NMR and IR spectroscopy. The formation of technetium-99m complexes was confirmed by HPLC. The lipophilicity of the technetium complexes was measured.

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.