Sheng Shi, Chao Xiong, Dongyun Bie, Zhongrong Fang, Jianhui Wang
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A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.</p><p><strong>Results: </strong>Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. AKI occurred less frequently among children who were administered ibuprofen than among those who were not (46 of 396 [11.6%] vs. 152 of 716 [21.2%], <i>p</i> < 0.001). Using the Cox regression model accounting for time-varying exposures, ibuprofen treatment was not associated with AKI (adjusted HR, 0.99; 95% CI 0.70-1.39, <i>p</i> = 0.932). This insignificant association was consistent across the sensitivity and subgroup analyses.</p><p><strong>Conclusions: </strong>Postoperative ibuprofen exposure in pediatric patients undergoing cardiac surgery was not associated with an increased risk of AKI.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880564/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery.\",\"authors\":\"Sheng Shi, Chao Xiong, Dongyun Bie, Zhongrong Fang, Jianhui Wang\",\"doi\":\"10.1080/0886022X.2024.2318417\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pediatric cardiac surgery has not been determined yet.</p><p><strong>Methods: </strong>In this retrospective cohort study, children undergoing cardiac surgery with cardiopulmonary bypass were studied. Exposure was defined as given ibuprofen in the first 7 days after surgery. Postoperative AKI was diagnosed using the KDIGO criteria. A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.</p><p><strong>Results: </strong>Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. AKI occurred less frequently among children who were administered ibuprofen than among those who were not (46 of 396 [11.6%] vs. 152 of 716 [21.2%], <i>p</i> < 0.001). Using the Cox regression model accounting for time-varying exposures, ibuprofen treatment was not associated with AKI (adjusted HR, 0.99; 95% CI 0.70-1.39, <i>p</i> = 0.932). 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引用次数: 0
摘要
背景:急性肾损伤(AKI)是小儿心脏手术后常见的并发症,与较差的预后有关。布洛芬在围手术期被广泛使用,会影响儿童的肾功能。然而,布洛芬暴露与小儿心脏手术后 AKI 之间的关系尚未确定:在这项回顾性队列研究中,研究对象是接受心肺旁路心脏手术的儿童。术后 7 天内服用布洛芬即为接触布洛芬。术后 AKI 的诊断采用 KDIGO 标准。将布洛芬作为时变协变量,使用多变量 Cox 回归模型评估布洛芬暴露与术后 AKI 之间的关系:在纳入的1112名儿童中,198名(17.8%)发生了AKI。共有 396 名儿童(35.6%)接触过布洛芬。与未服用布洛芬的儿童相比,服用布洛芬的儿童发生 AKI 的频率较低(396 例中的 46 例 [11.6%] 对 716 例中的 152 例 [21.2%],P = 0.932)。这种不显著的关联在敏感性分析和亚组分析中都是一致的:结论:接受心脏手术的儿科患者术后布洛芬暴露与AKI风险增加无关。
Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery.
Background: Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pediatric cardiac surgery has not been determined yet.
Methods: In this retrospective cohort study, children undergoing cardiac surgery with cardiopulmonary bypass were studied. Exposure was defined as given ibuprofen in the first 7 days after surgery. Postoperative AKI was diagnosed using the KDIGO criteria. A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.
Results: Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. AKI occurred less frequently among children who were administered ibuprofen than among those who were not (46 of 396 [11.6%] vs. 152 of 716 [21.2%], p < 0.001). Using the Cox regression model accounting for time-varying exposures, ibuprofen treatment was not associated with AKI (adjusted HR, 0.99; 95% CI 0.70-1.39, p = 0.932). This insignificant association was consistent across the sensitivity and subgroup analyses.
Conclusions: Postoperative ibuprofen exposure in pediatric patients undergoing cardiac surgery was not associated with an increased risk of AKI.
期刊介绍:
Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.