脓毒症诱发心肌功能障碍时初始钠尿肽的 Meta 分析。

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Biomarkers in medicine Pub Date : 2024-02-01 Epub Date: 2024-02-21 DOI:10.2217/bmm-2023-0605

Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao

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引用次数: 0

摘要

目的：研究初始脑钠肽 (BNP) 和 N 端 Pro-BNP (NT-proBNP) 与脓毒症 3.0 环境下脓毒症诱发心肌功能障碍 (SIMD) 检测的相关性。方法：检索了三个数据库，分析 SIMD 组和非 SIMD 组的初始 BNP 和 NT-proBNP 水平。结果：共纳入 18 项研究：共纳入 18 项研究，其中大部分研究根据超声心动图对 SIMD 进行了定义。SIMD 组的血液中初始 BNP 和 NT-proBNP 水平较高。NT-proBNP 高于某一临界值（>3000 pg/ml）是 SIMD 的独立危险因素，其对 SIMD 诊断的准确性为中等（汇总曲线下面积：0.81）。结论初始血液 BNP 和 NT-proBNP 水平有助于协助检测 SIMD，有必要开展进一步研究以确定 SIMD 的定义。

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Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction.

Aim: To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. Methods: Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. Results: Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0.81). Conclusion: Initial blood BNP and NT-proBNP levels are useful to assist in the detection of SIMD and further studies are warranted to determine the SIMD definition.

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.