分析欧米茄-3 临床试验,呼吁为预防痴呆症提供个性化补充剂。

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI:10.1080/14737175.2024.2313547
Nicolás Castellanos-Perilla, Miguel Germán Borda, Dag Aarsland, George E Barreto
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引用次数: 0

摘要

导言:需要采取有针对性的干预措施来延缓或预防神经退行性疾病的发生。不良的饮食习惯与认知能力下降有关,这就凸显了鱼类和多不饱和脂肪酸(PUFAs)健康饮食的益处。摄入欧米伽-3 多不饱和脂肪酸二十二碳六烯酸(DHA)、α-亚麻酸(ALA)和二十碳五烯酸(EPA)与健康老龄化、心血管益处和降低阿尔茨海默氏症风险有关。虽然欧米伽-3 对健康有益,但现代饮食中的欧米伽-3 摄入量往往不足。虽然鱼油补充剂提供了一种替代来源,但临床试验的结果不一致,使人们对决定其成功与否的因素产生了疑问:在这篇综述中,作者讨论了上述决定性因素,并强调了可提高ω-3 PUFAs干预痴呆症和认知能力下降的有效性的策略。此外,作者还对未来可能开展的研究提出了建议:饮食、生活方式和遗传倾向等因素都会影响ω-3补充剂的效果。在进行临床试验时,考虑这些因素并认识到它们对结果解释的潜在影响至关重要。重要的是要独立研究每个变量以及它们之间的相互作用。
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An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention.

Introduction: Targeted interventions are needed to delay or prevent the onset of neurodegenerative diseases. Poor dietary habits are associated with cognitive decline, highlighting the benefits of a healthy diet with fish and polyunsaturated fatty acids (PUFAs). Intake of omega-3 PUFAs docosahexaenoic acid (DHA), α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) is linked with healthy aging, cardiovascular benefits, and reduced risk of Alzheimer's disease. Although omega-3 has health benefits, its intake is often inadequate and insufficient in modern diets. Although fish oil supplements offer an alternative source, inconsistent results from clinical trials raise questions about the factors determining their success.

Areas covered: In this this review, the authors discuss the aforementioned determining factors and highlight strategies that could enhance the effectiveness of omega-3 PUFAs interventions for dementia and cognitive decline. Moreover, the authors provide suggestions for potential future research.

Expert opinion: Factors such as diet, lifestyle, and genetic predisposition can all influence the effectiveness of omega-3 supplementation. When implementing clinical trials, it is crucial to consider these factors and recognize their potential impact on the interpretation of results. It is important to study each variable independently and the interactions between them.

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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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