透视眼部疾病:Omics 科学在眼科研究中的关键作用

IF 4.6 Q1 CHEMISTRY, ANALYTICAL ACS Measurement Science Au Pub Date : 2024-02-22 DOI:10.1021/acsmeasuresciau.3c00067
Maurine Fucito, Matteo Spedicato, Simona Felletti, Angeli Christy Yu, Massimo Busin, Luisa Pasti, Flavio A. Franchina, Alberto Cavazzini, Chiara De Luca* and Martina Catani*, 
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引用次数: 0

摘要

精准医疗是一种新的医疗方法,它同时考虑了人群特征和个体差异,以提供量身定制的医疗服务。从传统的反应医学到个性化医学的转变是基于生物标志物驱动的过程和对疾病发生发展的生物机制的深入了解。在这种情况下,高通量 omics 技术的进步为发现新型生物标记物和提供生物系统的公正图像提供了一个独特的机会。眼科是最近开始应用全息技术的医学领域之一。眼部疾病非常常见,其中一些可能会造成严重的残疾,从而导致视力丧失和失明。大多数眼科疾病的致病机制可能取决于各种遗传和环境因素,而这些因素的影响尚未完全明了。在这种情况下,大规模全息方法是对整个系统进行全面评估的基础,也是开发新型疗法的重要工具。本综述总结了过去十年中应用于眼科的全局组学科学的最新进展,特别是从分析的角度重点介绍了蛋白质组学、代谢组学和脂质组学的应用。文章还讨论了高效分离技术与(高分辨率)质谱联用((HR)MS)的作用,以及作为分析工作流程整合部分的取样、样品制备和数据分析的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Look into Ocular Diseases: The Pivotal Role of Omics Sciences in Ophthalmology Research

Precision medicine is a new medical approach which considers both population characteristics and individual variability to provide customized healthcare. The transition from traditional reactive medicine to personalized medicine is based on a biomarker-driven process and a deep knowledge of biological mechanisms according to which the development of diseases occurs. In this context, the advancements in high-throughput omics technologies represent a unique opportunity to discover novel biomarkers and to provide an unbiased picture of the biological system. One of the medical fields in which omics science has started to be recently applied is that of ophthalmology. Ocular diseases are very common, and some of them could be highly disabling, thus leading to vision loss and blindness. The pathogenic mechanism of most ocular diseases may be dependent on various genetic and environmental factors, whose effect has not been yet completely understood. In this context, large-scale omics approaches are fundamental to have a comprehensive evaluation of the whole system and represent an essential tool for the development of novel therapies. This Review summarizes the recent advancements in omics science applied to ophthalmology in the last ten years, in particular by focusing on proteomics, metabolomics and lipidomics applications from an analytical perspective. The role of high-efficiency separation techniques coupled to (high-resolution) mass spectrometry ((HR)MS) is also discussed, as well as the impact of sampling, sample preparation and data analysis as integrating parts of the analytical workflow.

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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
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0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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