口腔溶解膜作为儿科用药的一种潜在剂型

Bhupendra G. Prajapati, Priyanka Patel, Dhirendra C. Patel
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引用次数: 0

摘要

制药业正在研究使用薄膜的给药系统。它们是一个多样化的平台,可以提供即时、局部或全身作用。此外,这些系统可以独立使用,非常适合吞咽困难患者、老人、儿童或卧床患者,以及饮水困难的患者。这些给药系统可通过口腔、颊部、舌下、眼部和经皮途径给药。本研究从当前的角度探讨了口腔薄膜的所有特性,深入分析了随着研究领域的不断扩大和技术的不断突破,口腔薄膜的市场份额也在不断增长。同时,本研究还总结了影响薄膜配方开发的关键因素,如薄膜设计、形态和生理限制、生产工艺选择、表征技术以及聚合物和药物的物理化学特性。本书还概述了主要制药公司最新生产的薄膜产品。
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Mouth dissolving film as a potential dosage form for paediatric usage
Drug delivery systems using thin films are being researched by the pharmaceutical industry. They're a diverse platform that can provide immediate, local, or systemic actions. Furthermore, these systems can be used independently, which is ideal for patients with dysphagia, elderly, pediatric, or bed-ridden patients, as well as those who may have difficulty consuming water. These drug delivery systems can be given by oral, buccal, sublingual, ocular and trans-dermal routes. This study explores mouth thin films in all of their characteristics from the current perspective, providing insight into the world's growing market share as a result of expanding research fields and technological breakthroughs. Simultaneously, It provides a summary of the key factors involved in formulation development that have an impact on thin films, such as thin film design, morphological and physiological limitations, production process selection, characterization techniques, and polymer and drug physicochemical properties. It also gives an overview of the most recent thin-film products made by major pharmaceutical firms.
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