孕期脂质代谢:对母婴的影响。

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI:10.1097/MOL.0000000000000927
Janneke W C M Mulder, D Meeike Kusters, Jeanine E Roeters van Lennep, Barbara A Hutten
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引用次数: 0

摘要

审查目的:为适应胎儿的生长发育,妇女在怀孕期间会经历多种生理变化。近年来,关于妊娠期高脂血症对母婴心血管风险的影响,已有多项研究积累了相关证据。本综述旨在从临床角度全面概述目前有关妊娠期血脂变化及其对母婴相关(心血管)结果的研究:在正常妊娠期,总胆固醇和低密度脂蛋白胆固醇水平大约会增加 30-50%,高密度脂蛋白胆固醇增加 20-40%,甘油三酯增加 50-100%。有些妇女,例如患有家族性高胆固醇血症(FH)的妇女,其血脂状况更易导致动脉粥样硬化。妊娠期血脂异常与母亲(如先兆子痫、妊娠糖尿病、代谢综合征、血脂异常)和胎儿(如早产、胎龄过大、动脉粥样硬化前病变、血脂异常)的不良(心血管)结局有关。更好地了解不良后果和特定风险群体,可以更好地进行风险评估,更早地预防心血管疾病。未来的研究应探讨实施妊娠筛查的可能性。图表摘要:http://links.lww.com/COL/A29。
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Lipid metabolism during pregnancy: consequences for mother and child.

Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on cardiovascular risk for mother and child. This review aims to provide a comprehensive overview of the current research on lipid profile alterations during pregnancy and its associated (cardiovascular) outcomes for mother and child from a clinical perspective.

Recent findings: In a normal pregnancy, total and LDL-cholesterol levels increase by approximately 30-50%, HDL-cholesterol by 20-40%, and triglycerides by 50-100%. In some women, for example, with familial hypercholesterolemia (FH), a more atherogenic lipid profile is observed. Dyslipidemia during pregnancy is found to be associated with adverse (cardiovascular) outcomes for the mother (e.g. preeclampsia, gestational diabetes, metabolic syndrome, unfavorable lipid profile) and for the child (e.g. preterm birth, large for gestational age, preatherosclerotic lesions, unfavorable lipid profile).

Summary: The lipid profile of women during pregnancy provides a unique window of opportunity into the potential future cardiovascular risk for mother and child. Better knowledge about adverse outcomes and specific risk groups could lead to better risk assessment and earlier cardiovascular prevention. Future research should investigate implementation of gestational screening possibilities.

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来源期刊
Current opinion in lipidology
Current opinion in lipidology 医学-内分泌学与代谢
CiteScore
6.70
自引率
4.50%
发文量
64
审稿时长
6-12 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
期刊最新文献
Are the lipid-lowering effects of incretin-based therapies relevant for cardiovascular benefit? From clinical development to real-world outcomes with inclisiran. Oral agents for lowering lipoprotein(a). Universal screening for familial hypercholesterolaemia: how can we maximise benefits and minimise potential harm for children and their families? A contemporary snapshot of familial hypercholesterolemia registries.
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