一例良性凸面原发性骨内脑膜瘤复发病例

NMC case report journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI:10.2176/jns-nmc.2023-0171
Masahiro Ueno, Shinji Shimato
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摘要

起源于颅骨内的脑膜瘤非常罕见,有报告称其为原发性骨内脑膜瘤(PIOM)。此外,位于颅底或有恶性病理改变的原发性骨内脑膜瘤容易复发,而位于凸面或有良性病理改变的原发性骨内脑膜瘤却很少复发。在此,我们介绍了一例良性病理的凸面骨内脑膜瘤广泛复发的病例。一名 72 岁的妇女因头痛来我院就诊。钆对比剂增强磁共振成像显示,左侧额叶至顶叶区域的肿瘤增强,肿瘤穿过颅骨,侵入硬膜下间隙和皮下组织。头颅X光片和计算机断层扫描发现病变部位有明显的溶骨性改变。对肿瘤和周围组织进行了显微镜下完全切除术(MCR)。肿瘤经组织病理学诊断为过渡性脑膜瘤(世界卫生组织 1 级)。术后七年,患者出现构音障碍,经检查发现肿瘤复发,大块病灶穿过犊骨延伸至眶骨,部分突入脑部和头皮。再次进行了 MCR,并使用钛板重建了颅骨的大面积髑髅区。由于复发性肿瘤的广泛性和罕见性,该病例非常独特。在此,我们将详细报告该病例的临床过程并讨论其特点。
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A Case of Recurrence of Benign Convexity Primary Intraosseous Meningioma.

Meningiomas originating within the bones of the skull are rare and have been reported as primary intraosseous meningiomas (PIOM). Moreover, PIOMs with a skull base location or malignant pathology are predisposed to recurrence; however, recurrence is quite rare among PIOMs characterized by a convexity location and benign pathology. Here, we present a case of extensive recurrence of a convex intraosseous meningioma with benign pathology. A 72-year-old woman presented with a headache to our hospital. Gd contrast-enhanced magnetic resonance imaging revealed an enhanced tumor in the left frontal to the parietal region extending through the calvarial bone and invading the subdural space and subcutaneous tissue. Skull radiograph and computed tomography identified a remarkable osteolytic change in the lesion. Macroscopic complete resection (MCR) of the tumor and the surrounding tissues was performed. The tumor was histopathologically diagnosed as a transitional meningioma (World Health Organization grade 1). Seven years after the surgery, the patient presented with dysarthria, and the recurrence of the tumor was identified as massive lesions extending through the calvarial bone to the orbital bone, partially protruding into the brain and scalp. MCR was performed again, with the reconstruction of the skull for an extensive calvarial area using a titanium plate. This case is unique due to the extensiveness of the recurrent tumor and its rarity. Here, we report the details of the clinical course and discuss the characteristics of this case.

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