Miguel Yael Carmona , Saúl André Vera , María De Fatima Higuera , Livan Delgado , Santiago Camacho
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引用次数: 0
摘要
引言和目的奥利司他是一种广泛用于超重/肥胖患者的药物，与左旋肉碱联合使用可改善这些患者的病情。据我们所知，这种联合用药对超重患者生活质量的影响尚未确定。我们的目的是评估奥利司他和左旋肉碱联合用药 4 周和 8 周后对患者生活质量的影响。材料和方法我们评估了 16 名患者（41.81±8.26（37.77-45.86）岁，81% 女性）在奥利司他和左旋肉碱联合用药 4 周和 8 周后的生活质量（短表格-36）。数据以平均 SD 和 95%IC 或百分比表示。我们采用配对学生 t 检验，双尾检验，α=0.05。患者体重降低了约 5%。患者在身体疼痛、一般健康、活力以及精神[45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46)，p=0.02]和体能[59.4±8.92 (55.03-63.77) vs. 63.36±3.21(48.31-51.46)，p=0.02]方面均有改善。结论这些结果表明奥利司他和左旋肉碱联合治疗超重具有良好效果。
P- 48 EFFECT OF THE COMBINATION OF ORLISTAT AND L-CARNITINE ON THE QUALITY OF LIFE (SF.36) IN 16 OVERWEIGTH PATIENTS
Introduction and Objectives
Orlistat is a drug widely used in overweight/obese patients, while the combination with l-carnitine could offer an improvement in these patients. To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined. We aimed to evaluate the effects on the quality of life of patients who took the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment.
Materials and Methods
We evaluated the quality of life (Short Form-36) in 16 patients [41.81±8.26 (37.77-45.86) years, 81% women] undergoing pharmacotherapy of the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Data express mean SD and 95%IC or percentages as correspond. We use paired Student t Test, two tails with an alpha=0.05.
Results
Figure. Patients lowered their weight in about 5%. Patients show improvement on body pain, general health, vitality and in both Mental [45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46), p=0.02] and Physical [59.4±8.92 (55.03-63.77) vs. 63.36±9.64 (58.63-68.08), p=0.01) summaries.
Conclusions
These results suggest a beneficial effect of the combination of Orlistat and l-carnitine on the treatment of overweight.
期刊介绍：
Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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