O- 8 PNPLA3 rs738409 c>g 多态性对巴西人群中与 HCV 相关的 HCC 发展的影响:初步结果

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of hepatology Pub Date : 2024-02-01 DOI:10.1016/j.aohep.2023.101258
Claudia Maccali, Aline L Chagas, Lisa Rc Saud, Regiane Ssm Alencar, Michele Sg Gouvea, Joyce Mks Etto, Isabel V Pereira, Arthur In Oliveira, Jose T Stefano, Rafael Sn Pinheiro, Wellington Andraus, Paulo Herman, Luiz Ac D'albuquerque, Mario G Pessoa, Claudia P Oliveira
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引用次数: 0

摘要

引言和目的PNPLA3 rs738409 C>G多态性与肝细胞癌(HCC)和肝硬化相关,与病因无关,但与非病毒性病因的相关性更强。然而,PNPLA3 多态性对丙型肝炎病毒(HCV)的影响以及该多态性是否会成为与 HCV 相关的 HCC 的风险因素,目前还没有明确的定义。我们的目的是评估 PNPLA3 rs738409 C>G 多态性对巴西 HCV 患者 HCC 发生风险的影响。材料与方法本研究纳入了 90 名在巴西一家三级中心接受肝移植或切除术的 HCV 相关肝硬化和 HCC 患者,以及 111 名非 HCV 相关肝硬化的 HCC 患者作为对照组。研究人员使用 TaqMan 法检测了从患者血液样本中提取的 DNA 中的 rs738409 多态性。所有临床数据均通过研究电子数据采集(REDCap)工具收集。统计分析使用 Jamovi 软件 2.3.23 版进行。结果在 HCV+HCC 组中,男性(79.1% 对 45.9%,p<0.001)、酗酒史(80.5% 对 22.5%,p<0.001)和吸烟史(68.9% 对 25.2%,p<0.001)的比例较高,但两组患者在年龄(p=0.519)和体重指数(p=0.403)方面没有统计学差异。HCV+HCC组的rs738409多态性基因型频率为CC 41.2%、CC和CG/GG 58.8%,对照组为CC 49.5%、CG/GG 50.5%。结论即使在巴西这样的混血人群中,PNPLA3 rs738409 C>G多态性与罹患HCV相关HCC的风险之间也没有关联,这与之前在白种人和东方人中已发表的研究结果一致。
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O- 8 PNPLA3 RS738409 C>G POLYMORPHISM IMPACT ON HCV-RELATED HCC DEVELOPMENT IN THE BRAZILIAN POPULATION: PRELIMINARY RESULTS

Introduction and Objectives

The PNPLA3 rs738409 C>G polymorphism has been associated with hepatocellular carcinoma (HCC) and liver cirrhosis regardless of the etiology, although the association was stronger with non-viral etiologies. However, the influence of PNPLA3 polymorphism on Hepatitis C Virus (HCV) and whether this polymorphism could be a risk factor for HCV-related HCC is not well defined. We aimed to evaluate the influence of the PNPLA3 rs738409 C>G polymorphism on the risk of HCC occurrence in HCV patients in Brazil.

Materials and Methods

This study included 90 patients with HCV-related cirrhosis and HCC who underwent liver transplantation or resection at a tertiary center in Brazil and 111 patients non-HCC with HCV-related cirrhosis, as the control group. The rs738409 polymorphism was detected in the DNA extracted from patients' blood samples using the TaqMan assay. All clinical data were collected using the Research Electronic Data Capture (REDCap) tool. The statistical analyses were performed using Jamovi software version 2.3.23.

Results

In the HCV+HCC group there was a higher proportion of male gender (79.1% vs. 45.9%, p<0.001), history of alcoholism (80.5% vs. 22.5%, p<0.001) and smoking (68.9% vs. 25.2%, p<0.001), however there was no statistical difference in age (p=0.519) and BMI (p=0.403) between both groups. The genotype frequencies of the rs738409 polymorphism in the HCV+HCC group was CC 41,2% CC and CG/GG 58,8% vs. controls CC 49,5% and CG/GG 50,5%. The presence of the G allele was not an independent factor associated with the risk of HCC occurrence (r=0,199, p=0.53).

Conclusions

Even in an admixed population such as the Brazilian, there was no association between the PNPLA3 rs738409 C>G polymorphism and the risk of developing HCV-related HCC, as previously shown in published studies in caucasian and oriental population.

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来源期刊
Annals of hepatology
Annals of hepatology 医学-胃肠肝病学
CiteScore
7.90
自引率
2.60%
发文量
183
审稿时长
4-8 weeks
期刊介绍: Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
期刊最新文献
Editorial board Global multi-societies endorsement of the MAFLD definition An Acknowledgement Biological aging accelerates hepatic fibrosis: Insights from the NHANES 2017-2020 and genome-wide association study analysis. Development of a biodegradable prosthesis through tissue engineering, for the organ-replacement or substitution of the extrahepatic bile duct
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