鹅(Anser anser domesticus)口服德拉克西布的药代动力学评估。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-02-29 DOI:10.1111/jvp.13435
Charbel Fadel, Beata Łebkowska-Wieruszewska, Amnart Poapolathep, Firas Serih, Krzysztof Bourdo, Mario Giorgi
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引用次数: 0

摘要

在动物福利问题日益受到关注的推动下,兽医将疼痛治疗纳入了禽类物种的治疗范围,而禽类物种的微妙和非特异性行为体征给治疗带来了挑战。鉴于传统非甾体抗炎药的安全性问题凸显了在鸟类中使用更有针对性的替代品的必要性,本研究探讨了Deracoxib(DX)的药动学(PK)特性,DX是一种COX-2选择性非甾体抗炎药,已被批准用于狗,在鹅体内单次口服给药后的药动学特性。六只健康雌鹅接受了 4 毫克/千克的 DX 给药。分别在 0、0.25、0.5、0.75、1、1.5、2、4、6、8、10 和 24 小时从左翼静脉抽血至肝素化试管。结果表明,DX 的终末半衰期为 6.3 小时,Tmax 为 1 小时,未观察到不良反应。虽然不能根据单次剂量就断言绝对安全,但值得强调的是,有必要对鹅进行进一步的 DX 安全性研究,这表明有可能间歇性使用。此外,关于疗效和适用性的结论还有待进一步研究,尤其是在了解鹅特有的 COX-2 选择性和蛋白质结合特性方面。
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Pharmacokinetic evaluation of oral deracoxib in geese (Anser anser domesticus)

The integration of pain management in veterinary practice, driven by heightened animal welfare concerns, extends to avian species where subtle and nonspecific behavioral signs pose challenges. Given that safety concerns with classical NSAIDs highlight the need for more targeted alternatives in birds, this study explores the pharmacokinetic (PK) properties of Deracoxib (DX), a COX-2 selective NSAID approved for use in dogs, following a single oral administration in geese. Six healthy female geese received 4 mg/kg DX. Blood was drawn from the left wing vein to heparinized tubes at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, and 24 h. Plasma DX concentrations were measured using HPLC coupled to an UV detector, and the data were pharmacokinetically analyzed using PKanalix™ software in a non-compartmental approach. The results indicated a terminal half-life of 6.3 h and a Tmax of 1 h, with no observed adverse effects. While refraining from claiming absolute safety based on a single dose, it is worth highlighting that further safety studies for DX in geese are warranted, suggesting a possibility for intermittent use. In addition, drawing conclusions on efficacy and suitability awaits further research, particularly in understanding COX-2 selectivity and protein binding characteristics specific to geese.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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