肾胰高血糖素受体对肾脏代谢和平衡功能至关重要

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-02-29 DOI:10.1038/s41581-024-00825-1
Ellen F. Carney
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引用次数: 0

摘要

肾脏胰高血糖素受体(GCGRs)沿肾小球表达,并在慢性肾脏病(CKD)中下调;然而,人们对它们的生理功能还不甚了解。研究人员报告说,组成型或诱导型肾特异性基因敲除 Gcgr 的成年小鼠表现出肾功能障碍和代谢异常,包括葡萄糖耐量和胰岛素敏感性增加;肾葡萄糖输出减少;高氨基酸血症;全身氮、水和电解质平衡失调;慢性氧化应激;尿液和血清电解质谱改变。此外,这些小鼠还伴有高血压、心脏肥大的结构特征和肾脏损伤迹象,包括肾脏损伤生物标志物和白蛋白尿水平升高。
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The renal glucagon receptor is essential to kidney metabolic and homeostatic functions
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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