肌肉疏松症对接受根治性膀胱切除术的膀胱癌患者预后的影响:系统回顾与荟萃分析。

IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Scottish Medical Journal Pub Date : 2024-05-01 Epub Date: 2024-02-29 DOI:10.1177/00369330241234690
Fanyi Qin, Jiacheng Wu
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引用次数: 0

摘要

摘要提供有关肌肉疏松症与接受根治性膀胱切除术(RC)的膀胱癌患者的死亡率、复发率及术后并发症风险之间关系的综合证据:仅纳入了对接受根治性膀胱切除术的膀胱癌患者中肌肉疏松症与相关结果之间关系进行调查的观察性设计研究。相关结果包括死亡率、复发率和术后并发症。系统性检索使用了三个大型数据库,即 PubMed、EMBASE 和 Scopus。分析采用随机效应模型,汇总效应大小以几率比(OR)或危险比(HR)以及 95% 置信区间(CI)的形式报告:结果:共纳入了 21 项研究,4997 名患者。与非肌肉疏松症患者相比,肌肉疏松症患者的全因死亡率(HR 1.45,95% CI:1.32,1.61)、癌症特异性死亡率(HR 1.74,95% CI:1.49,2.03)和无复发生存率(HR 1.84,95% CI:1.30,2.62)均有所增加。肌肉疏松症患者在术后90天内出现并发症的风险也更高(OR 1.77,95% CI:1.23,2.55):膀胱癌患者中的肌肉疏松症与不良的生存结果和术后并发症风险增加有关。
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Impact of sarcopenia on outcomes of bladder cancer undergoing radical cystectomy: A systematic review and meta-analysis.

Objective: To provide synthesized evidence on the association between sarcopenia and risk of mortality, recurrence and postoperative complications in patients with bladder cancer and undergoing radical cystectomy (RC).

Methods: Only studies with observational design that investigated the association between sarcopenia and outcomes of interest among patients with bladder cancer undergoing RC were included. The outcomes of interest were mortality, recurrence, and postoperative complications. The systematic search was conducted using three large databases, that is, PubMed, EMBASE, and Scopus. A random effects model was used for the analysis and pooled effect sizes were reported as odds ratio (OR) or hazards ratio (HR) along with 95% confidence intervals (CIs).

Results: A total of 21 studies with 4997 patients were included. Compared to non-sarcopenic subjects, those with sarcopenia had increased risk of all-cause mortality (HR 1.45, 95% CI: 1.32, 1.61), cancer-specific mortality (HR 1.74, 95% CI: 1.49, 2.03) and a lower recurrence free survival (HR 1.84, 95% CI: 1.30, 2.62). Patients with sarcopenia also had higher risk of developing complications within 90 days postoperatively (OR 1.77, 95% CI: 1.23, 2.55).

Conclusion: Sarcopenia among patients with bladder cancer and managed using RC is associated with adverse survival outcomes and an increased risk of postoperative complications.

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来源期刊
Scottish Medical Journal
Scottish Medical Journal 医学-医学:内科
CiteScore
4.80
自引率
3.70%
发文量
42
审稿时长
>12 weeks
期刊介绍: A unique international information source for the latest news and issues concerning the Scottish medical community. Contributions are drawn from Scotland and its medical institutions, through an array of international authors. In addition to original papers, Scottish Medical Journal publishes commissioned educational review articles, case reports, historical articles, and sponsoring society abstracts.This journal is a member of the Committee on Publications Ethics (COPE).
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