胆道闭锁相关生物标志物的研究进展。

IF 3.1 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Clinical and Translational Hepatology Pub Date : 2024-03-28 Epub Date: 2024-01-30 DOI:10.14218/JCTH.2023.00260
Fanyang Kong, Rui Dong, Gong Chen, Song Sun, Yifan Yang, Jingying Jiang, Lingdu Meng, Huifen Chen, Jiajie Zhu, Shan Zheng
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引用次数: 0

摘要

胆道闭锁(BA)是一种先天性胆汁淤积性疾病,会严重损害儿童的肝功能。它是儿童进行肝移植的主要原因之一。胆道闭锁的早期诊断对患者的预后至关重要,但目前仍缺乏可靠的无创诊断方法。此外,由于部分患儿急需进行肝移植手术,因此采用一种直接、高效、创伤小的方法评估 BA 患儿的肝纤维化阶段和术后原肝存活率是医生们关注的重点。近年来,越来越多与 BA 相关的生物标志物被发现,并在临床实践的以下三个方面显示出巨大的潜力:诊断、肝纤维化阶段评估和原肝存活率预测。本综述将重点讨论三种新型 BA 相关生物标记物(即 MMP-7、FGF-19 和 M2BPGi)的病理生理功能和临床应用。此外,还讨论了 BA 的知名生物标志物(如γ-谷氨酰转移酶、循环细胞因子和其他潜在生物标志物)的研究进展,旨在为临床实践提供参考。
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Progress in Biomarkers Related to Biliary Atresia.

Biliary atresia (BA) is a congenital cholestatic disease that can seriously damage children's liver function. It is one of the main reasons for liver transplantation in children. Early diagnosis of BA is crucial to the prognosis of patients, but there is still a lack of reliable non-invasive diagnostic methods. Additionally, as some children are in urgent need of liver transplantation, evaluating the stage of liver fibrosis and postoperative native liver survival in children with BA using a straightforward, efficient, and less traumatic method is a major focus of doctors. In recent years, an increasing number of BA-related biomarkers have been identified and have shown great potential in the following three aspects of clinical practice: diagnosis, evaluation of the stage of liver fibrosis, and prediction of native liver survival. This review focuses on the pathophysiological function and clinical application of three novel BA-related biomarkers, namely MMP-7, FGF-19, and M2BPGi. Furthermore, progress in well-known biomarkers of BA such as gamma-glutamyltransferase, circulating cytokines, and other potential biomarkers is discussed, aiming to provide a reference for clinical practice.

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来源期刊
Journal of Clinical and Translational Hepatology
Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.40
自引率
2.80%
发文量
496
期刊最新文献
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