天然产物生物合成过程中不寻常的酶促 C-C 键形成和裂解反应

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL Chemical & pharmaceutical bulletin Pub Date : 2024-03-01 DOI:10.1248/cpb.c23-00889

Richiro Ushimaru

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引用次数: 0

摘要

来自植物和微生物的天然产物是宝贵的药物化合物宝库。C-C 键的形成和裂解是天然产物生物合成过程中的关键事件，在生成对生物功能至关重要的多种复杂化学结构方面发挥着关键作用。本综述总结了我们最近在天然产物生物合成过程中催化非常规 C-C 键形成和裂解反应的生物合成酶方面的发现。

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Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis

Natural products from plants and microorganisms provide a valuable reservoir of pharmaceutical compounds. C–C bond formation and cleavage are crucial events during natural product biosynthesis, playing pivotal roles in generating diverse and intricate chemical structures that are essential for biological functions. This review summarizes our recent findings regarding biosynthetic enzymes that catalyze unconventional C–C bond formation and cleavage reactions during natural product biosynthesis.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.