功能性中性粒细胞疾病:慢性肉芽肿病及其他。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-03-01 DOI:10.1111/imr.13308
Christa S. Zerbe, Steven M. Holland
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引用次数: 0

摘要

自从梅契尼科夫在 1905 年描述了吞噬细胞以来,人们越来越认识到,吞噬细胞是一种实体,它能到达感染和炎症部位,吞噬并杀死感染生物,清除凋亡碎片,同时为淋巴器官提供抗原,供其日后使用。因此,吞噬细胞是宿主保护和免疫反应的门户和第一道关卡。杀伤力和趋化性失调不仅会导致感染易感性,还会导致自身免疫。我们旨在描述慢性肉芽肿病和白细胞粘附缺陷以及髓过氧化物酶缺乏症和 G6PD 缺乏症作为关键途径的范例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Functional neutrophil disorders: Chronic granulomatous disease and beyond

Since their description by Metchnikoff in 1905, phagocytes have been increasingly recognized to be the entities that traffic to sites of infection and inflammation, engulf and kill infecting organisms, and clear out apoptotic debris all the while making antigens available and accessible to the lymphoid organs for future use. Therefore, phagocytes provide the gateway and the first check in host protection and immune response. Disorders in killing and chemotaxis lead not only to infection susceptibility, but also to autoimmunity. We aim to describe chronic granulomatous disease and the leukocyte adhesion deficiencies as well as myeloperoxidase deficiency and G6PD deficiency as paradigms of critical pathways.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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