细胞因子和可溶性介质是癌症治疗中肿瘤微环境重编程的设计师

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2024-02-28 DOI:10.1016/j.cytogfr.2024.02.003
Suling Xu , Qingqing Wang , Wenxue Ma
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引用次数: 0

摘要

在错综复杂的肿瘤微环境(TME)中,细胞因子和可溶性介质成为抗击癌症的双刃剑。这篇综述超越了传统视角,揭示了这些元素在癌症动力学中既是盟友又是对手的微妙相互作用。它批判性地评估了TME重编程不断演变的范例,重点介绍了针对细胞因子和介质复杂网络的创新策略。文章特别关注揭示新型细胞因子和介质的治疗潜力,尤其是它们与细胞外囊泡之间的协同作用,因为细胞外囊泡是尚未充分开发的治疗靶向渠道。针对当前研究中存在的重大空白,我们探讨了这些生化角色在协调免疫反应、肿瘤增殖和转移方面尚未开发的潜力。这篇综述倡导范式转变,利用肿瘤组织器官内的这些动态相互作用,旨在超越传统治疗方法,为精准肿瘤学的新时代铺平道路。通过对最新进展的批判性综述,我们强调了利用细胞因子和介质的全方位活动的创新方法的必要性,为提高特异性、降低毒性和改善患者预后的突破性疗法奠定了基础。
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Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy

Navigating the intricate landscape of the tumor microenvironment (TME) unveils a pivotal arena for cancer therapeutics, where cytokines and soluble mediators emerge as double-edged swords in the fight against cancer. This review ventures beyond traditional perspectives, illuminating the nuanced interplay of these elements as both allies and adversaries in cancer dynamics. It critically evaluates the evolving paradigms of TME reprogramming, spotlighting innovative strategies that target the sophisticated network of cytokines and mediators. Special focus is placed on unveiling the therapeutic potential of novel cytokines and mediators, particularly their synergistic interactions with extracellular vesicles, which represent underexplored conduits for therapeutic targeting. Addressing a significant gap in current research, we explore the untapped potential of these biochemical players in orchestrating immune responses, tumor proliferation, and metastasis. The review advocates for a paradigm shift towards exploiting these dynamic interactions within the TME, aiming to transcend conventional treatments and pave the way for a new era of precision oncology. Through a critical synthesis of recent advancements, we highlight the imperative for innovative approaches that harness the full spectrum of cytokine and mediator activities, setting the stage for breakthrough therapies that offer heightened specificity, reduced toxicity, and improved patient outcomes.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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