非侵入性迷走神经刺激预处理可减轻小鼠闭合性颅脑损伤后的神经功能障碍

IF 1.8 Q3 CLINICAL NEUROLOGY Neurotrauma reports Pub Date : 2024-02-29 eCollection Date: 2024-01-01 DOI:10.1089/neur.2023.0058
Andreia Morais, Joon Yong Chung, Limin Wu, Cenk Ayata, Bruce Simon, Michael J Whalen
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引用次数: 0

摘要

无创迷走神经刺激(nVNS)最近被认为是治疗创伤性脑损伤(TBI)的一种潜在疗法。我们曾证实,无创迷走神经刺激可抑制皮层扩散性去极化(偏头痛先兆的电生理基础),并与创伤性脑损伤相关。我们过去的研究还表明,白细胞介素-1β(IL-1β)在小鼠闭合性头部损伤(CHI)后的认知障碍中发挥作用。我们的研究表明,nVNS 预处理可抑制 CHI 相关的空间学习和记忆损伤,并防止损伤神经元中的 IL-1β 激活,但不能防止内皮细胞中的 IL-1β 激活。相反,CHI 10 分钟后给予 nVNS 则无效。这些数据表明,在脑震荡性创伤的高危人群中,nVNS 预防可改善与脑震荡相关的神经元功能障碍。
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Non-Invasive Vagal Nerve Stimulation Pre-Treatment Reduces Neurological Dysfunction After Closed Head Injury in Mice.

Non-invasive vagus nerve stimulation (nVNS) has recently been suggested as a potential therapy for traumatic brain injury (TBI). We previously demonstrated that nVNS inhibits cortical spreading depolarization, the electrophysiological event underlying migraine aura, and is relevant to TBI. Our past work also suggests a role for interleukin-1 beta (IL-1β) in cognitive deficits after closed head injury (CHI) in mice. We show that nVNS pre-treatment suppresses CHI-associated spatial learning and memory impairment and prevents IL-1β activation in injured neurons, but not endothelial cells. In contrast, nVNS administered 10 min after CHI was ineffective. These data suggest that nVNS prophylaxis might ameliorate neuronal dysfunction associated with CHI in populations at high risk for concussive TBI.

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