Yongqi Zhang, Ying Guan, Shuxiang Wang, Chunyan Guan, Xiaoli Liu
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引用次数: 0
摘要
综述的目的：在这篇综述中，我们总结了已发表的有关三方基序（TRIM）家族成员在人类恶性肿瘤的发生和发展中的作用的文章：泛素-蛋白酶体系统（UP-S）在细胞活动中发挥着关键作用，UP-S失调会导致肿瘤发生。UP-S的关键调控因子之一是三方基序TRIM蛋白家族，其中大多数是活性E3泛素连接酶。TRIM 蛋白对癌细胞的生物功能至关重要，包括迁移、侵袭、转移和耐药性。因此，了解 TRIM 蛋白如何在癌细胞的分子水平上发挥作用非常重要。我们建议将 TRIM 家族成员作为克服治疗失败的潜在新标记物和靶点。
Tripartite motif family - its role in tumor progression and therapy resistance: a review.
Purpose of review: In this review, we summarized published articles on the role of tripartite motif (TRIM) family members in the initiation and development of human malignancies.
Recent findings: The ubiquitin-proteasome system (UP-S) plays a critical role in cellular activities, and UP-S dysregulation contributes to tumorigenesis. One of the key regulators of the UP-S is the tripartite motif TRIM protein family, most of which are active E3 ubiquitin ligases. TRIM proteins are critical for the biological functions of cancer cells, including migration, invasion, metastasis, and therapy resistance. Therefore, it is important to understand how TRIM proteins function at the molecular level in cancer cells.
Summary: We provide a comprehensive and up-to-date overview about the role TRIMs play in cancer progression and therapy resistance. We propose TRIM family members as potential new markers and targets to overcome therapy failure.
期刊介绍：
With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.
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