使用左炔诺孕酮宫内节育器治疗异常子宫出血的妇女与使用该节育器避孕的妇女在临床概况和结果上是否存在差异？一项横断面比较研究。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-04 DOI:10.4274/tjod.galenos.2024.51460

Maryam Al Shukri, Maryam Said, Asha Nair, Mariam Mathew, Vaidyanatahn Gowri

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引用次数: 0

摘要

目的：左炔诺孕酮宫内节育器（LNG-IUD）最常见的适应症是避孕和治疗异常子宫出血（AUB）。本研究旨在探讨使用左炔诺孕酮宫内节育器避孕和处理异常子宫出血的妇女在临床概况和结果方面的差异：这是一项回顾性比较横断面研究，研究对象为 2012 年至 2017 年期间接受 LNG-IUD （52 毫克）治疗的女性。对她们的电子健康记录进行了审查，直至最后一次有记录的随访或直至 2021 年 12 月：共有 235 名妇女接受了 LNG-IUD 治疗，年龄在 21 岁至 62 岁之间，平均年龄为（37.98 岁±6.76）岁。其中，153/235（65.1%）名妇女为避孕而上环，82/235（34.89%）名妇女为 AUB 而上环。随访时间为 1-94 个月，AUB 组的随访时间（平均值 ± SEM）为（21.48±2.31）个月，避孕组为（20.74±1.76）个月（P 值为 0.80）。两组妇女在年龄和体重指数（BMI）方面存在明显差异，其中因 AUB 而接受 LNG-IUD 治疗的妇女年龄较大（平均为（42.54±6.49）岁，P 值为 2，P 值 =0.011）。所有用于避孕的液化天然气宫内节育器都是在门诊植入的。然而，在 AUB 中，68.3%的人是在手术室与宫腔镜检查同时进行的。结论：本研究表明，与使用 LNG-IUD 进行避孕的妇女相比，使用 LNG-IUD 治疗 AUB 的妇女年龄更大，体重指数更高。与避孕组相比，AUB 妇女经历了更多的排出，但在 LNG-IUD 的总体存活率/保留率方面，两组之间没有差异。

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Is there a difference in the clinical profile and outcome of women using levonorgestrel IUD for abnormal uterine bleeding and those using it for contraception?: A comparative cross-sectional study.

Objective: The most common indications for Levonorgestrel intrauterine device (LNG-IUD) are contraception and management of abnormal uterine bleeding (AUB). This study was conducted with the aim of exploring the differences in the clinical profile and outcome of women using LNG-IUD for contraception and AUB.

Materials and methods: This was a retrospective comparative cross-sectional study of women who underwent LNG-IUD (52 mg) between 2012 and 2017. Their electronic health records were reviewed until the last documented follow-up or until December 2021.

Results: A total of 235 women had LNG-IUD with an age range of 21 to 62 years and a mean of (37.98 years±6.76). Of these women, 153/235 (65.1%) had it for contraception and 82/235 (34.89%) had it for AUB. The follow-up was 1-94 months with (mean ± SEM) follow-up for the AUB group of (21.48±2.31) months and for contraception group was (20.74±1.76) months (p-value of 0.80). There was a significant difference between the two groups in the age and body mass index (BMI), where women who had LNG-IUD for AUB were older (mean of 42.54±6.49 years, p-value <0.001) and had higher BMI (31.88±7.52 kg/m², p-value =0.011). All LNG-IUDs that were indicated for contraception were inserted in an outpatient setting. However, 68.3% in the AUB, the insertion was in the operating theater in conjunction with hysteroscopy. After combining both expulsion and removal of LNG-IUD during the follow-up period, there was no significant difference between the 2 groups in the overall retention rate during the follow-up (p-value =0.998).

Conclusion: this study shows that women using LNG-IUD for the management of AUB are older and have a higher BMI compared with those using it for contraception. AUB women experienced more expulsion compared with the contraception group, but there was no difference between the 2 groups in the overall survival/retention of LNG-IUD.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.