孟德尔随机研究:肠道微生物群在败血症中的作用--谁是角度?

Polish journal of microbiology Pub Date : 2024-03-04 eCollection Date: 2024-03-01 DOI:10.33073/pjm-2024-006
Yeping Bian, Jian Xu, Xiaojing Deng, Suming Zhou
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引用次数: 0

摘要

肠道微生物群(GM)是脓毒症发病机制中一个至关重要的潜在因素。然而,其因果关系尚不明确,仍有待确定。我们进行了一项双样本孟德尔随机研究。研究人员评估了从全基因组关联研究中总结的有关脓毒症和 GM 的统计数据。工具变量被定义为与暴露有显著相关性的单核苷酸多态性。反方差加权检验作为孟德尔随机分析的一种主要方法,被用来估计因果关系。逆方差加权分析结果表明,在不同类群水平上,放线菌和双歧杆菌科对败血症有影响。在编码为 ieu-b-69 的结果中,放线菌在门级(β = -0.34,SE = 0.10,p = 0.0008)和类级(β = -0.23,SE = 0.07,p = 0.0011)与败血症风险呈负相关。在编码为 ieu-b-4980 的结果中,门级放线菌(β = -0.22,SE = 0.10,p = 0.027)也与败血症呈负相关。双歧杆菌科的目级(β = -0.20,SE = 0.06,p = 0.0021)、科级(β = -0.20,SE = 0.06,p = 0.0021)和属级(β = -0.20,SE = 0.06,p = 0.0007)均与结果编码为 ieu-b-69 的败血症风险呈负相关。Wald ratio 模型的结果显示,Tyzzerella 属(OR (95%CI) = 0.6902[0.4907,0.9708], p = 0.0331)和 Gastranaerophilales 目(OR (95%CI) = 0.5907[0.3516,0.9926], p = 0.0468)与败血症呈负相关。这项研究表明,在不同类群水平上,放线菌和双歧杆菌科、Tyzzerella属和嗜胃肠菌目与败血症有因果关系,表明它们是败血症发病率的保护因素。
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A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis - Who is the Angle?

Gut microbiota (GM) is a crucial underlying player during sepsis pathogenesis. However, the causal relationship is unclear and remains to be determined. A two-sample Mendelian randomization study was implemented. The statistical data about sepsis together with GM summarized from genome-wide association studies were evaluated. Instrumental variables were defined as single-nucleotide polymorphisms with prominent correlations with exposure. The inverse-variance-weighted test was employed as a major approach of Mendelian randomization analysis to estimate of causal relationships. The inverse-variance-weighted analysis results demonstrated that at different taxa levels, Actinobacteria and Bifidobacteriaceae influence sepsis. Actinobacteria had negative relationships to sepsis risk at the phylum (β = -0.34, SE = 0.10, p = 0.0008) and class (β = -0.23, SE = 0.07, p = 0.0011) levels in outcome coded ieu-b-69. Actinobacteria at the phylum level (β = -0.22, SE = 0.10, p = 0.027) was also negatively associated with sepsis in outcome coded ieu-b-4980. Bifidobacteriaceae at the order (β = -0.20, SE = 0.06, p = 0.0021), family (β = -0.20, SE = 0.06, p = 0.0021), and genus (β = -0.20, SE = 0.06, p = 0.0007) levels were all negatively correlated with the risk of sepsis in outcome coded ieu-b-69. The results of the Wald ratio model showed that Tyzzerella genus (OR (95%CI) = 0.6902[0.4907,0.9708], p = 0.0331) and Gastranaerophilales order (OR (95%CI) = 0.5907[0.3516,0.9926], p = 0.0468) were negatively connected with sepsis. This study implied at different taxa levels Actinobacteria and Bifidobacteriaceae, Tyzzerella genus, and Gastranaerophilales order have a causal relationship with sepsis, indicating that they are protective factors for the incidence of sepsis.

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