补充欧米伽-3 脂肪酸对接受透析的 ESRD 患者的血红蛋白、血细胞比容和血小板水平的影响

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2024-02-23 DOI:10.1016/j.jtauto.2024.100233

Zahra Mahmoudi , Zahra Roumi , Seyed Ali Askarpour , Zahra Mousavi , Hanieh Shafaei , Neda Valisoltani , Mahsa Shapouri , Seyed Reza Mirshafaei , Pouya Mirzaee , Khadijeh Abbasi Mobarakeh , Elahe Taghavi Sufiani , Zeinab Motiee Bijarpasi , Zeynab Motiei , Masoud Khosravi , Saeid Doaei , Maryam Gholamalizadeh

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引用次数: 0

摘要

背景接受血液透析（HD）的终末期肾病（ESRD）患者合并炎症可能会增加心血管并发症。奥米加-3 脂肪酸可能对血液透析患者的健康有一定的益处。本研究旨在调查补充欧米伽-3 脂肪酸对血液透析患者的血细胞比容 (HCT)、血红蛋白 (HB) 水平和血小板 (PLT) 计数的影响。干预组（55 人）每天服用三粒欧米伽-3 脂肪酸补充胶囊（3 克/天），为期两个月。对照组（n = 60）服用三粒含有中链甘油三酯（MCT）油的安慰剂胶囊，剂量与干预组同期的补充剂量相似。结果与对照组相比，干预组的 PLT 计数下降（173.38 ± 74.76 vs. 227.68 ± 86.58 103/mm3，F = 4.83，P = 0.03）。结论HD患者补充omega-3可降低血管内形成血栓的风险。有必要进行进一步研究。

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The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis

Background

Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients.

Methods

A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran. Three omega-3 fatty acid supplement capsules (3 g/d) were administered daily for two months to patients in the intervention group (n = 55). The control group (n = 60) were given three placebo capsules containing medium chain triglyceride (MCT) oil, similar to the supplemental dose of the intervention group at the same period. Three parameters of HCT, HB and PLT were measured at baseline and after the intervention.

Results

The PLT count decreased in the intervention group compared to the control group (173.38 ± 74.76 vs. 227.68 ± 86.58 10³/mm³, F = 4.83, P = 0.03). No significant change was found on the levels of HCT and HB parameters between the two groups after the intervention.