年评分在肺栓塞诊断中的预测准确性

Hussien Fayiad, Heba Moussa, Yara Nosair, Amira Ismail Mostafa
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摘要

肺动脉栓塞(PE)是一种突发性肺动脉阻塞,通常与急性右心室衰竭导致的高死亡率有关。早期诊断非常重要,因为大多数患者会在发病后数小时内死亡。紧急处理通常非常有价值,而且右心衰竭可能是可逆的。多载体计算机断层扫描肺动脉造影术(CTPA)是记录急性肺栓塞的最佳诊断成像方式。过度使用 CTPA 会增加不必要的辐射风险,增加恶性肿瘤、造影剂相关过敏性休克和急性肾损伤的风险。为了避免这些问题,使用可变的 D 二聚体临界值结合临床症状对疑似急性肺栓塞进行简化评分,可以安全地排除肺栓塞。评估 YEARS 评分与 CTPA 相比在肺栓塞诊断中的预测准确性,从而减少 CTPA 的过度使用。研究在 Kasr ElAini 医院胸科进行。50 名患者接受了病史、检查、Wells 评分计算、D-二聚体、YEARS 评分和 CTPA 检查。结果显示,在 50 名参与研究的患者中,YEARS 评分可成功预测 80% 的患者是否患有 PE。YEARS 评分的灵敏度为 90%,特异性为 65%。YEARS评分为零且D-二聚体≥1000 ng/ml的患者,以及YEARS评分≥1分且D-二聚体≥500 ng/ml的患者,都有可能被YEARS算法判定为PE,灵敏度为90%。通过 YEARS 评分,我们可以排除 YEARS 评分为零、D-二聚体˂ 1000 ng/ml 的患者以及 YEARS 评分≥ 1 分、D-二聚体˂ 500 ng/ml 的患者的肺栓塞,特异性为 65%,从而减少了在诊断 PE 时过度使用 CTPA。
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Predictive accuracy of years score in diagnosis of pulmonary embolism
Pulmonary embolism (PE) is a sudden obstruction of pulmonary arteries usually associated with a high rate of mortality due to acute right ventricular failure. Early diagnosis is of much importance because most patients die within the first hours of presentation. Emergency management is usually highly valuable and right heart failure is potentially reversible. Multidetector computed tomography pulmonary angiography (CTPA) is the best diagnostic imaging modality to document acute pulmonary embolism. Overuse of CTPA increases the unrequired risk of radiation exposure, increasing the risk of malignancy, contrast-related anaphylaxis, and acute kidney injury. To abolish these issues, the simplified score for suspected acute pulmonary embolism using variable D dimer cut-off value in combination with clinical signs can exclude pulmonary embolism safely. To evaluate the predictive accuracy of YEARS score in the diagnosis of pulmonary embolism compared to CTPA that might lead to a decrease in the overuse of CTPA. The study was held at the chest unit in Kasr ElAini hospitals. It included 50 patients, for which full history, examination, calculation of wells score, D-dimer, YEARS score, and CTPA were done. The results showed that the YEARS score succeeded in predicting the presence or the absence of PE in 80% of the 50 enrolled patients in our study. YEARS score has a sensitivity of 90% and specificity of 65%. Patients with zero YEARS score and D-dimer ≥ 1000 ng/ml as well as those with ≥ 1 YEARS score and D-dimer ≥ 500 ng/ml are rendered PE likely by the YEARS algorithm with a sensitivity of 90%. Using years score, we can exclude pulmonary embolism in patients with zero YEARS score and a D-dimer ˂ 1000 ng/ml as well as in patients with ≥ 1 YEARS score and D-dimer ˂ 500 ng/ml with 65% specificity, thus decreasing overuse of CTPA in the diagnosis of PE.
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