从基因组到临床:转化生物信息学在改善人类健康方面的力量。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI:10.1016/bs.apcsb.2023.11.010
Satyendra Singh, Anurag Kumar Pandey, Vijay Kumar Prajapati
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引用次数: 0

摘要

转化生物信息学(TBI)通过整合基因组数据和临床信息,提供个性化医疗和量身定制的治疗方案,从而改变了医疗保健。近年来,由于量子计算等信息学领域的重大进展以及最先进技术的应用,转化生物信息学已在基因组和临床数据之间架起了一座桥梁。本章讨论了转化生物信息学在改善人类健康方面的力量,包括发现致病基因和变异,以及建立新的治疗技术。我们讨论了生物信息学在临床基因组学中的关键应用领域,如转化生物信息学中使用的数据源和方法、转化生物信息学对人类健康的影响,以及如何利用机器学习和人工智能挖掘海量数据用于药物开发和精准医疗。我们还探讨了与利用基因组数据相关的问题、限制和伦理问题,以及转化生物信息学的未来及其对医学和人类健康的潜在影响。最后,本章强调了转化生物信息学在改变医疗保健和提高患者疗效方面的巨大潜力。
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From genome to clinic: The power of translational bioinformatics in improving human health.

Translational bioinformatics (TBI) has transformed healthcare by providing personalized medicine and tailored treatment options by integrating genomic data and clinical information. In recent years, TBI has bridged the gap between genome and clinical data because of significant advances in informatics like quantum computing and utilizing state-of-the-art technologies. This chapter discusses the power of translational bioinformatics in improving human health, from uncovering disease-causing genes and variations to establishing new therapeutic techniques. We discuss key application areas of bioinformatics in clinical genomics, such as data sources and methods used in translational bioinformatics, the impact of translational bioinformatics on human health, and how machine learning and artificial intelligence are being used to mine vast amounts of data for drug development and precision medicine. We also look at the problems, constraints, and ethical concerns connected with exploiting genomic data and the future of translational bioinformatics and its potential impact on medicine and human health. Ultimately, this chapter emphasizes the great potential of translational bioinformatics to alter healthcare and enhance patient outcomes.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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