在两项基于人口的研究中寻找与碳水化合物摄入量减少和 NTD 风险相关的因素。

IF 1.6 4区 医学 Q4 DEVELOPMENTAL BIOLOGY Birth Defects Research Pub Date : 2024-03-07 DOI:10.1002/bdr2.2328
Gary M. Shaw, Wei Yang, Kari A. Weber, Andrew F. Olshan, Tania A. Desrosiers, The National Birth Defects Prevention Study
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引用次数: 0

摘要

背景:两项基于人群的病例对照研究报告称,围孕期低碳水化合物饮食的妇女受神经管缺陷(NTD)影响的妊娠风险增加。鉴于只有两项研究调查了这一关联,目前还不清楚研究结果在多大程度上会受到残余混杂因素的影响。在此,我们进一步询问了观察到这种关联的两项研究,目的是从更多的因素中找出可能解释这种关联的因素:通过使用机器学习算法(随机森林),我们调查了200多个变量的基线集。这些分析产生了每个数据集中预测围孕期低碳水化合物摄入量的病例和对照组的前 10 个变量:结果:通过逻辑回归模型对这些预测变量进行研究,我们没有发现任何一个特定的变量对两组数据中NTD与低碳水化合物的关联有实质性的影响:结论:如果有潜在的因素可以解释这种关联,我们的研究结果表明,我们研究的 200 多个变量中没有一个与真正的解释性暴露充分相关。另外,我们的研究结果还可能表明,还有其他未确定的因素在起作用,或者在两组独立数据中观察到的关联与低碳水化合物摄入量直接相关。
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A search for factors associated with reduced carbohydrate intake and NTD risk in two population-based studies

Background

Two population-based case–control studies have reported an increased risk of neural tube defect (NTD)-affected pregnancies among women with low carbohydrate diet in the periconceptional period. Given that only two studies have investigated this association, it is unclear to what degree the findings could be impacted by residual confounding. Here, we further interrogated both studies that observed this association with the objective to identify factors from a much larger number of factors that might explain the association.

Methods

By employing a machine learning algorithm (random forest), we investigated a baseline set of over 200 variables. These analyses produced the top 10 variables in each data set for cases and controls that predicted periconceptional low carbohydrate intake.

Results

Examining those prediction variables with logistic regression modeling, we did not observe any particular variable that substantially contributed to the NTD-low carbohydrate association in either data set.

Conclusions

If there are underlying factors that explain the association, our findings suggest that none of the 200+ variables we examined were sufficiently correlated with what that true explanatory exposure may be. Alternatively, our findings may suggest that there are other unidentified factor(s) at play, or the association observed in two independent data sets is directly related to low carbohydrate intake.

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来源期刊
Birth Defects Research
Birth Defects Research Medicine-Embryology
CiteScore
3.60
自引率
9.50%
发文量
153
期刊介绍: The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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