Julia Nolting, Romy Nitzsche, Bernhard Kiss, Oliver W Hakenberg, Laila Schneidewind
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Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function).</p><p><strong>Outcomes: </strong>The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival.</p><p><strong>Results: </strong>Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. Interestingly, the general health score is significantly correlated to sexual satisfaction (Pearson's correlation; <i>r</i> = 0.522, <i>P</i> = .002) preoperatively but not following surgery: <i>r</i> = 0.103 (<i>P</i> = .665) after 3 months, <i>r</i> = 0.478 (<i>P</i> = .052) after 6 months, <i>r</i> = 0.276 (<i>P</i> = .302) after 9 months, and <i>r</i> = 0.337 (<i>P</i> = .202) after 12 months. The importance of a sex life is still essential for the patients, especially when recovering from RC; nearly the same can be reported for elderly patients. Unfortunately, the data for women are too limited to report robust results.</p><p><strong>Clinical implications: </strong>Evaluation, advice, and monitoring of sexual health must be integrated into clinical practice, particularly in women.</p><p><strong>Strengths and limitations: </strong>At least to our knowledge, this is the first systematic prospective evaluation of sexual health in patients with BC receiving RC. Due to the small sample size, there is a risk of selection bias.</p><p><strong>Conclusion: </strong>Sexual health is important for patients with BC receiving RC, and it is an essential part of quality of life, especially in elderly patients.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915580/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prospective evaluation of sexual health following radical cystectomy due to bladder cancer.\",\"authors\":\"Julia Nolting, Romy Nitzsche, Bernhard Kiss, Oliver W Hakenberg, Laila Schneidewind\",\"doi\":\"10.1093/sexmed/qfae005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is a lack of data concerning sexual health following open radical cystectomy (RC), especially in elderly patients and women.</p><p><strong>Aim: </strong>To describe sexual health and its impact on general health as well as survival in patients undergoing standard open RC for the treatment of bladder cancer (BC). 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Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function).</p><p><strong>Outcomes: </strong>The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival.</p><p><strong>Results: </strong>Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. 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引用次数: 0
摘要
背景：目的：描述接受标准开放式膀胱根治术（RC）治疗膀胱癌（BC）患者的性健康及其对总体健康和生存的影响。由于数据有限，我们对老年患者和女性患者进行了亚组分析：我们进行了一项前瞻性非介入临床研究，评估了因膀胱癌而接受任何一种尿路改道手术的膀胱癌患者在手术后 12 个月的随访中的性健康情况。该研究获得了当地伦理审查委员会的批准（A 2021-0175），并在德国临床试验注册中心进行了注册（DRKS00026255）。性健康评估采用以下经过验证的问卷：EORTC QLQ-C30（生活质量；欧洲癌症研究和治疗组织）、EORTC SH22（性健康）和 IIEF-5（5 项勃起功能国际指数）：结果：EORTC QLQ-C30、EORTC SH22和IIEF-5的标准测量值以及总生存率：32名患者参与了研究，平均年龄为71.5岁（SD，9.7）：其中男性 25 人（78.1%），女性 7 人（21.9%）。总体而言，研究对象的性健康情况各不相同，但手术前的性满意度明显较高，而性生活的重要性则保持在较高水平且稳定。有趣的是，术前一般健康评分与性满意度有明显的相关性（皮尔逊相关性；r = 0.522，P = .002），但术后却没有：3 个月后 r = 0.103 (P = .665)，6 个月后 r = 0.478 (P = .052)，9 个月后 r = 0.276 (P = .302)，12 个月后 r = 0.337 (P = .202)。性生活的重要性对患者来说仍然至关重要，尤其是在 RC 恢复期；老年患者的情况也几乎如此。遗憾的是，女性患者的数据过于有限，无法报告可靠的结果：临床意义：必须将性健康的评估、建议和监测纳入临床实践，尤其是女性患者：至少就我们所知，这是首次对接受 RC 治疗的 BC 患者的性健康进行系统的前瞻性评估。由于样本量较小，存在选择偏倚的风险：性健康对接受 RC 治疗的 BC 患者非常重要，是生活质量的重要组成部分，尤其是对老年患者而言。
Prospective evaluation of sexual health following radical cystectomy due to bladder cancer.
Background: There is a lack of data concerning sexual health following open radical cystectomy (RC), especially in elderly patients and women.
Aim: To describe sexual health and its impact on general health as well as survival in patients undergoing standard open RC for the treatment of bladder cancer (BC). Due to limited data, subgroup analysis for elderly patients and women was performed.
Methods: A prospective noninterventional clinical study was performed evaluating sexual health in RC with any kind of urinary diversion due to BC with a follow-up of 12 months after RC. The study was approved by the local ethics review board (A 2021-0175) and was registered at the German Clinical Trial Register (DRKS00026255). Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function).
Outcomes: The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival.
Results: Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. Interestingly, the general health score is significantly correlated to sexual satisfaction (Pearson's correlation; r = 0.522, P = .002) preoperatively but not following surgery: r = 0.103 (P = .665) after 3 months, r = 0.478 (P = .052) after 6 months, r = 0.276 (P = .302) after 9 months, and r = 0.337 (P = .202) after 12 months. The importance of a sex life is still essential for the patients, especially when recovering from RC; nearly the same can be reported for elderly patients. Unfortunately, the data for women are too limited to report robust results.
Clinical implications: Evaluation, advice, and monitoring of sexual health must be integrated into clinical practice, particularly in women.
Strengths and limitations: At least to our knowledge, this is the first systematic prospective evaluation of sexual health in patients with BC receiving RC. Due to the small sample size, there is a risk of selection bias.
Conclusion: Sexual health is important for patients with BC receiving RC, and it is an essential part of quality of life, especially in elderly patients.
期刊介绍：
Sexual Medicine is an official publication of the International Society for Sexual Medicine, and serves the field as the peer-reviewed, open access journal for rapid dissemination of multidisciplinary clinical and basic research in all areas of global sexual medicine, and particularly acts as a venue for topics of regional or sub-specialty interest. The journal is focused on issues in clinical medicine and epidemiology but also publishes basic science papers with particular relevance to specific populations. Sexual Medicine offers clinicians and researchers a rapid route to publication and the opportunity to publish in a broadly distributed and highly visible global forum. The journal publishes high quality articles from all over the world and actively seeks submissions from countries with expanding sexual medicine communities. Sexual Medicine relies on the same expert panel of editors and reviewers as The Journal of Sexual Medicine and Sexual Medicine Reviews.
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