纳米管对人类精液质量和生育能力的影响:文献系统综述。

IF 1.4 Q3 UROLOGY & NEPHROLOGY Archivio Italiano di Urologia e Andrologia Pub Date : 2024-03-07 DOI:10.4081/aiua.2024.12192
William Felipe Fernández Zapata, Yamile Cardona Maya, Cesar Isaza Merino, Walter D Cardona Maya
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引用次数: 0

摘要

背景:在医疗领域,纳米管的使用越来越普遍,例如在给药方面。然而,由于在动物实验中观察到纳米管对激素水平和精子质量的潜在影响,因此纳米管引起了对男性生育能力的担忧。此外,动物暴露于多壁碳纳米管模型中会导致激素水平、精子活力和精子数量发生变化。人类的有限证据表明没有不良影响,但仍需进一步研究。本研究旨在对纳米管对人类精液和生育能力的体外影响进行系统性回顾评估:我们纳入了所有已发表的关于人类精液或精子或男性生育能力和纳米管的体外研究。截至 2023 年 5 月,我们在 LILACS、PubMed 和 SCOPUS 中进行了检索。使用 QUIN 工具对偏倚风险进行了评估:结果:纳入了四项关于人类精子使用纳米管的研究,暴露于纳米管似乎不会影响精子的存活率;但是,有报告称,精子的运动性、速度和活性氧的产生发生了一些变化。由于出版物数量较少,因此提供的证据有限:结论:纳米管似乎不会对人类精子产生不利影响。
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Effects of nanotubes on semen quality and fertility in humans: A systematic review of literature.

Background: In the medical field, it is increasingly common to observe the use of nanotubes, for example, in the administration of drugs. However, nanotubes raise concerns for male fertility due to potential effects on hormone levels and sperm quality observed in animal studies. In addition, animal exposure to multi-walled carbon nanotube models found alterations in hormone levels, sperm motility, and sperm count. Limited evidence in humans suggests no adverse effects, but further research is needed. This study aimed to perform a systematic review to assess the in vitro effects of nanotubes on semen and fertility in humans.

Methods: We included all published in vitro studies about semen or sperm or male fertility and nanotubes in humans. A search was conducted in LILACS, PubMed, and SCOPUS as of May 2023. The risk of bias was assessed using the QUIN tool.

Results: Four studies using nanotubes on human sperm were included, nanotubes exposure appears not to affect sperm viability; however, some alterations to motility, velocity and production of reactive oxygen species were reported. Limited evidence is provided because of the small quantity of publications.

Conclusions: Nanotubes appear to have no adverse effects on human sperm.

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来源期刊
CiteScore
2.10
自引率
35.70%
发文量
72
审稿时长
10 weeks
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