Ioana Medrea, Stewart J. Tepper, Donliang Wang, Paul G. Mathew, Mark Burish
{"title":"丛集性头痛临床试验设计 2022 指南评述及进一步建议","authors":"Ioana Medrea, Stewart J. Tepper, Donliang Wang, Paul G. Mathew, Mark Burish","doi":"10.1186/s10194-024-01732-3","DOIUrl":null,"url":null,"abstract":"New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies. We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment. We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.","PeriodicalId":501630,"journal":{"name":"The Journal of Headache and Pain","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions\",\"authors\":\"Ioana Medrea, Stewart J. Tepper, Donliang Wang, Paul G. Mathew, Mark Burish\",\"doi\":\"10.1186/s10194-024-01732-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies. We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment. We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.\",\"PeriodicalId\":501630,\"journal\":{\"name\":\"The Journal of Headache and Pain\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Headache and Pain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s10194-024-01732-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Headache and Pain","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s10194-024-01732-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies. We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment. We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.
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