油辣木叶乙醇提取物可对抗氯化铝诱导的大鼠大脑皮层神经变性。

IF 2.2 4区 医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-03-05 eCollection Date: 2024-04-01 DOI:10.1093/toxres/tfae028
Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi
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引用次数: 0

摘要

背景:铝是一种公认的神经毒素,与多种神经退行性疾病有关。油杉(Moringa oleifera,M. oleifera)被称为神奇之树,可作为功能性食品和营养补充剂。本研究探讨了油橄榄提取物对氯化铝(AlCl3)诱导的大鼠大脑皮层神经退行性病变的潜在预防作用:将 24 只成年雄性 Wistar 大鼠随机分为四组:阴性对照组、油橄榄提取物(MOE)组、AlCl3 组和 AlCl3 + MOE 组。连续 28 天口服治疗。对认知能力、脑氧化/亚硝基应激、神经炎症、细胞凋亡以及相关的组织病理学改变进行了评估:结果表明:MOE改善了空间学习和记忆,提高了抗氧化剂超氧化物歧化酶的活性,拮抗了亚硝基应激,减少了炎症细胞因子(肿瘤坏死因子-α和白细胞介素-6),降低了caspase-3,增加了Bcl-2,并促进了大脑皮层和海马结构的修复:我们得出结论:MOE 对大脑皮层神经退行性变具有保护作用,使其成为一种很有前景的补充剂,可对抗铝引起的神经毒性效应。
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Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats.

Background: Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of M. oleifera extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.

Materials and methods: Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, M. oleifera extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.

Results: Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.

Conclusions: We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.

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Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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